In our last week's #journalclub, we looked at how the dynein light chain LC8 stablises the disordered domain of KANK1, transforming it into a rigid, hinged rod that can span the cortex–microtubule gap and recruit kinesin-4 to cortical microtubule plus ends.

www.biorxiv.org/content/10.1...

Today in #JournalClub we discussed a new preprint that uses in situ cryo-ET and molecular dynamics simulations to study biomolecular condensate formation. Very beautiful data and interesting insights. Check it out!
www.biorxiv.org/content/10.6...

Beautiful images from @christlet.bsky.social labelling tubulin in neurons #journalclub
www.biorxiv.org/content/10.6...

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...

As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ