transiently associates with them, and induces their retrograde transport via dynein and the microtubule network toward a perinuclear region near the microtubule-organizing center (MTOC), where the vRNPs remain sequestered.

Finally taking the time to post about the fantastic conference #NSV2025, which was held at the #Corum, here in #Montpellier, South of France, and co-organized by Paul Duprex, Wendy Barclay, Sean Whelan and @oliviermoncorge.bsky.social! My whole team was there and we had a fantastic time!

One of the perks of often coming to Paris for work and sometimes having free evenings: (re)discovering its beauty! tonight #NotreDame 🤩

Taking a break from evaluations to analyse some confocal images I took this week on IFs I did with bronchial ciliated cells from @arebendenne.bsky.social 🤩

#FluorescenceFriday

The team Secret Santa 2024! Not so many decoys this year but quality ones 😂

And we observed that, conversely, ATM inhibition (with AZD0156) potently inhibit SARS2 replication! This also works against seasonal HCoV-229E, suggesting a conserved mechanism for these human CoVs, and in multiple cellular models. 4/5

The master DNA Damage Response kinase ATM, which lies in a resting state associated to Goldi-bound P4P in the cytoplasm (see fantastic previous work from María!), is displaced upon SARS2 replication, and massively activated... 3/5

Like other +RNA viruses forming DMVs to replicate, SARS-CoV-2 needs PI4P (as shown with decreased replication with PIK93 inhibitor) and hijacks OSBP1 to get it! Inhibition of OSBP1 induces a potent decrease in replication (while GOLPH3 and SAC1 silencing increase replication) 2/5

Working on Negative Strand RNA viruses? Here is the THE meeting you don't want to miss in 2025: #NSV2025!
It will take place in vibrant Montpellier, South of France, and is organized by Wendy Barclay, Paul Duprex, Sean Whelan and Olivier Moncorgé

Please share widely! #ViroSky #LoveVirology

Woh, discovering the absolutely stunning paper just published by @di-nunzio-lab.bsky.social and collaborators including @mammano.bsky.social. Fantastic read for my train journey back to Montpellier tonight! 🤩🤩 www.embopress.org/doi/epdf/10....
Congrats to all authors!

Thrilled to have been trained on our brand new Miltenyi Tyto cell sorter and cell cytometer MACSQuant16, both placed in our BSL3 @irim-life.bsky.social.
Great training by Esther Dalko and Cyril Longé from #Miltenyi!
Really looking forward to use these equipments for our ERC-funded project InVIRium!

#Montpellier #CoeurDeVilleEnLumieres 🤩

Delighted to share our latest preprint: www.biorxiv.org/content/10.1...
This study, led by our former PhD student and microscopy lover Joe McKellar, shows that human restriction factor MX1 associates transiently to trafficking, neo-synthesized influenza A virus vRNPs, ...

Fantastic PhD defense yesterday for now Dr Antoine Rebendenne, who had been co-supervized for his PhD by Mélanie Wencker (CIRI) and myself (IRIM). Thank you to his amazing evaluation panel: Volker thiel, Sam Wilson, Sandie Munier, Nolwenn Jouvenet, Monsef Benkirane, Uriel Hazan. And congrats Antoine

We are looking for 2 postdocs (a molecular virologist and a bioinfomatician with wet lab experience) to work on our ERC-funded InVIRium project! We're based in Montpellier, France and we aim to better characterize respiratory virus replication in pertinent models of primary airway epithelia.