Organised by

@andreas-t-schaefer.bsky.social, @em-stp.bsky.social, @carlesbosch.bsky.social, @safekhan.bsky.social, @jkbrmn.bsky.social, @yuxinzhang.bsky.social & Anika Tailor

Register here:
tinyurl.com/crickxrays25

#CrickXrays25 is organised by @andreas-t-schaefer.bsky.social, @em-stp.bsky.social, @carlesbosch.bsky.social, @safekhan.bsky.social, @jkbrmn.bsky.social & @yuxinzhang.bsky.social with the assistance of Anika Tailor.

Hard X-ray imaging of biological soft tissues.
tinyurl.com/crickxrays25

Join us!

With invited speakers from @esrf.fr, Northwestern U, ALBA, DESY-@embl.org, @psich.bsky.social, Argonne National Lab, @uni-goettingen.de, TU Denmark, @yaleschoolofmed.bsky.social, @crick.ac.uk, @ucl.ac.uk and from industry partners @dectris.bsky.social and @webknossos.org.

tinyurl.com/crickxrays25

Kudos to all authors involved and thanks to all the institutions that have hosted and supported this research, including the #synchrotrons DESY and @esrf.fr.

@crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @uclnpp.bsky.social

And to the whole team: Alfred Laugros, Jayde Livingstone, Manuel Berning, Sina Tootoonian, Mihaly Kollo, Andrea Nathansen and @normanrz.com

@crick.ac.uk @uclnpp.bsky.social @esrf.fr @psich.bsky.social @zeiss-microscopy.bsky.social @webknossos.org @mpibrain.bsky.social

Enjoy the read!

Cheers to @tobiasackels.bsky.social, with whom we started the correlative workflow, to Anne Bonnin, key in the SXRT datasets that articulate the pipeline, and to Carsten Waltenberg for milling a targeted cylinder containing the neuronal circuits.

@psich.bsky.social @zeiss-microscopy.bsky.social

Big shoutout to all collaborators. Starting with @yuxinzhang.bsky.social, whose PhD evolved building this story. To @andreas-t-schaefer.bsky.social, core PI in this endeavour, and @apacureanu.bsky.social and Peter Cloetens for the expert insight on X-ray holotomography.

@crick.ac.uk @esrf.fr

We developed our correlative multimodal imaging pipeline to incorporate Synchrotron X-ray Holographic Nanotomography.
With it we mapped a targeted 0.3mm^3 volumes with subcellular detail, non-destructively.

With sufficient reliability to gather 3 replicates of the same neuronal circuit.

In a nutshell, neurons of the same olfactory circuit in the mammalian brain share firing properties while showing individual traits.

Check out the tweetorial below by @yuxinzhang.bsky.social for the main findings:

bsky.app/profile/yuxi...

That’s amazing, congrats everyone!!