Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation"
bit.ly/43P7xJG
@vubasicsciences.bsky.social @vanderbilt.edu

New work from the @lpjacksonlab.bsky.social uses a combination of biochemical, biophysical and computational modeling techniques to investigate endosomal trafficking players. Congrats to 1st author @mintuju.bsky.social!
bit.ly/4hYry4o
@vubasicsciences.bsky.social @vandybiomed.bsky.social

We need scientists more than ever in light of current developments. I hope all of us advocate strongly for what we do and why to friends, family, and representatives in our local and federal governments.

Recent work from Ray Blind & collaborators suggests that multiple inositol phosphate species can dynamically regulate mTOR & mTORC1 by promoting a stable, more soluble active state of the kinase.
www.vanderbilt.edu/csb/2025/01/...
@vubasicsciences.bsky.social @cameronicohen.bsky.social

Check out TOMOMAN, a MATLAB-based package developed by the @williamnwan.bsky.social lab to act as a wrapper for external packages, storing metadata and interfacing the various packages used in each step of cryo-ET preprocessing ... bit.ly/3W49zB4

#structuralbiology @cameronicohen.bsky.social

Read more about new insights from @dougkojetin.bsky.social. He takes a deep dive into the structural binding poses of PPARγ ligands which was recently published in @elife.bsky.social ...
bit.ly/41rsKIq
#nmr #crystallography #structuralbiology
@cameronicohen.bsky.social @vubasicsciences.bsky.social