Prof David Wraith
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Prof David Wraith
@cameron-wraith.bsky.social
1.4K followers 290 following 23 posts
Erstwhile immunologist still working on designing antigen-specific immunotherapies for autoimmune diseases
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From Valley of the temples: Agrigento. A wonderful setting for a perfect statement.
September 25, 2025 at 10:36 AM
cameron-wraith.bsky.social
Good to see our article proposing a new approach to the effective control of autoimmune diseases beyond Immune Reset. ‘Immune reset plus’: the case for combining immunotherapies to maintain self-tolerance in autoimmune diseases in Frontiers in Immunology: www.frontiersin.org/journals/imm...
Immune reset plus: this figure illustrates the advantage of combining Immune Reset by B cell depletion with antigen-specific immunotherapy. ASIT with antigens delivered to tolerogenic APC can ‘switch off’ autoreactive T cells while promoting differentiation of antigen-specific regulatory T cell populations. Most importantly, ASIT approaches have been shown to function in B cell depleted animal models. Tolerance induction by ASIT depends on antigen presentation by steady state dendritic cells in lymphoid organs or by APC in the tolerogenic environment of the liver. Immune reset plus ASIT will enable disease to be controlled without continued B cell depletion. This will allow the treated individual to control infections and respond to vaccines.
July 23, 2025 at 12:05 PM