CAMEO-3D
@cameo3d.org
https://www.cameo3d.org/
CAMEO (Continuous Automated Model EvalutatiOn) is a community project to continuously evaluate the accuracy and reliability of 3D complex structure predictions.
Developed by @sib.swiss and @biozentrum.unibas.ch.
CAMEO (Continuous Automated Model EvalutatiOn) is a community project to continuously evaluate the accuracy and reliability of 3D complex structure predictions.
Developed by @sib.swiss and @biozentrum.unibas.ch.
Runs N' Poses is a great example of how to rigorously filter protein–ligand complexes for structural similarity: www.biorxiv.org/content/10.1....
August 8, 2025 at 7:48 AM
Runs N' Poses is a great example of how to rigorously filter protein–ligand complexes for structural similarity: www.biorxiv.org/content/10.1....
💡Note: these are sequences where the only template available is < 40% sequence identity, making it already a stricter scenario than usual splits with 2021 training cutoffs.
August 8, 2025 at 7:48 AM
💡Note: these are sequences where the only template available is < 40% sequence identity, making it already a stricter scenario than usual splits with 2021 training cutoffs.
Even at 40% sequence identity, SWISS-MODEL models have an LDDT greater than 0.7 on average. If you want to build a meaningful validation set without leakage, you need to adopt a significantly more stringent criterion.
August 8, 2025 at 7:48 AM
Even at 40% sequence identity, SWISS-MODEL models have an LDDT greater than 0.7 on average. If you want to build a meaningful validation set without leakage, you need to adopt a significantly more stringent criterion.
We looked at 3891 past CAMEO targets (January 2020 to April 2024). We plotted the LDDT of homology-based SWISS-MODEL prediction against the sequence identity of the top BLAST template, filtering for hits with at least 80% coverage of the target sequence.
August 8, 2025 at 7:48 AM
We looked at 3891 past CAMEO targets (January 2020 to April 2024). We plotted the LDDT of homology-based SWISS-MODEL prediction against the sequence identity of the top BLAST template, filtering for hits with at least 80% coverage of the target sequence.
Create your account and register your server now!
cameo3d.org
cameo3d.org
April 28, 2025 at 8:00 AM
Create your account and register your server now!
cameo3d.org
cameo3d.org
Detailed per-target scores and interactive 3D visualization.
April 28, 2025 at 7:56 AM
Detailed per-target scores and interactive 3D visualization.
Custom timeframes, automatic server comparisons on shared targets, multi-metric evaluations, and interactive boxplots for selected servers.
April 28, 2025 at 7:56 AM
Custom timeframes, automatic server comparisons on shared targets, multi-metric evaluations, and interactive boxplots for selected servers.