Guest Editors:
🧪 Suvarna Alladi
🔬 Atanu Biswas
🧪 Sinjan Ghosh
🔬 Faheem Arshad

A&D Editor-in-Chief: Donna Wilcock @wilcocklab.bsky.social

Please contact the editors if there are concerns regarding publication fees.

Interested in our other outstanding work on sialylation? Check out my other first-authored publications

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pubmed.ncbi.nlm.nih.gov/36867284/

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onlinelibrary.wiley.com/doi/full/10....

This work was supported by my amazing PhD mentors @hoppzor.bsky.social and Dr. Kevin Bieniek, @uthealthsa.bsky.social and all co-authors👏

Check out our publication now! #ADRD

Comparing across AD+CAA cases, there were less differences between sialylation levels in the space surrounding arterioles or the peri-vascular space. Further supporting CAA-driven increase in intra-vascular sialylation!

Histologically, we determined AD+CAA brains have increased sialylation intravascularly compared to “pure AD” brains. Potentially suggesting the intersection of this PTM and vessel vulnerability🧠

We focused on sialylation location in AD brains with Cerebral Amyloid Angiopathy (CAA)🩸. The increasing prevalence of ARIA events related to anti-amyloid therapies makes this work vitally important. We found significant differences in sialylation location between “pure AD” and AD+CAA!