1) Vascular contributions to neurodegeneration need more attention
2) Treating small vessel disease could delay or prevent cognitive decline
3) We need a holistic approach beyond amyloid & tau when thinking about dementia risk
1) Vascular contributions to neurodegeneration need more attention
2) Treating small vessel disease could delay or prevent cognitive decline
3) We need a holistic approach beyond amyloid & tau when thinking about dementia risk
Most dementia research focuses on Alzheimer’s pathology, but vascular disease independently contributes to cognitive impairment. This work highlights the heterogeneity of dementia-related pathologies and the importance of vascular health in dementia prevention.
Most dementia research focuses on Alzheimer’s pathology, but vascular disease independently contributes to cognitive impairment. This work highlights the heterogeneity of dementia-related pathologies and the importance of vascular health in dementia prevention.
1) Arteriolosclerosis (small vessel disease) is associated with worse memory, executive function, and language performance in decedents without severe dementia.
2)These effects persist even after adjusting for Alzheimer’s pathology (Aβ/tau) and Lewy body disease.
1) Arteriolosclerosis (small vessel disease) is associated with worse memory, executive function, and language performance in decedents without severe dementia.
2)These effects persist even after adjusting for Alzheimer’s pathology (Aβ/tau) and Lewy body disease.
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