Christoph Handschin
@c-handschin.bsky.social
Researcher @biozentrum.bsky.social of @unibasel.bsky.social in 🇨🇭. Skeletal #muscle plasticity / #exercise / #neuromuscular diseases / #aging / #metabolism / #PGC-1alpha
https://biozentrum.unibas.ch/handschin
https://biozentrum.unibas.ch/handschin
Pretty cool and surprising findings on different myonuclear populations and mononuclear cell behavior, e.g. in multicellular crosstalk using fixed tissue sequencing, minimizing cell activation by enzymatic digestion. Work led by @sedatdilbaz.bsky.social @biozentrum.unibas.ch @unibas.ch.
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November 14, 2025 at 2:34 PM
Pretty cool and surprising findings on different myonuclear populations and mononuclear cell behavior, e.g. in multicellular crosstalk using fixed tissue sequencing, minimizing cell activation by enzymatic digestion. Work led by @sedatdilbaz.bsky.social @biozentrum.unibas.ch @unibas.ch.
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If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
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doi.org/10.1101/2025...
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doi.org/10.1101/2025...
Muscle Fiber- and Cell Type-Specificity of Training Adaptation in Male Mice
Skeletal muscle possesses extraordinary plasticity of structure, metabolism, and function in response to repeated contractile activity. As a syncytium embedded within a complex microenvironment, muscl...
doi.org
November 14, 2025 at 2:34 PM
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
2/3
doi.org/10.1101/2025...
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doi.org/10.1101/2025...
Great - thanks!
August 20, 2025 at 12:34 PM
Great - thanks!
Hi Monica,
could you add me to Science feed please? Thanks!
Google Scholar: scholar.google.com/citations?us...
could you add me to Science feed please? Thanks!
Google Scholar: scholar.google.com/citations?us...
scholar.google.com
August 20, 2025 at 9:15 AM
Hi Monica,
could you add me to Science feed please? Thanks!
Google Scholar: scholar.google.com/citations?us...
could you add me to Science feed please? Thanks!
Google Scholar: scholar.google.com/citations?us...
Editorial by Scott Steen, CEO of the @apsphysiology.bsky.social
Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer
academic.oup.com/function/art...
Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer
academic.oup.com/function/art...
Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer
We are living through a moment of unprecedented challenge for science in the United States. A few months ago, as the Chief Executive Officer (CEO) of the A
academic.oup.com
July 10, 2025 at 2:30 PM
Editorial by Scott Steen, CEO of the @apsphysiology.bsky.social
Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer
academic.oup.com/function/art...
Science Is at a Crossroads—and Physiology With It: A Statement from the APS Chief Executive Officer
academic.oup.com/function/art...
This and much more! This review is an extension of, and complementary to our previous commentary in NPJ Aging (doi.org/10.1038/s415...), and the discussion in our review in the Journal of Physiology @physoc.bsky.social (doi.org/10.1113/jp28...).
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Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging
Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...
doi.org
March 28, 2025 at 12:55 PM
This and much more! This review is an extension of, and complementary to our previous commentary in NPJ Aging (doi.org/10.1038/s415...), and the discussion in our review in the Journal of Physiology @physoc.bsky.social (doi.org/10.1113/jp28...).
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8.) Our current health care setting fails to prioritize such measures. What could be done to improve the situation? On the level of the individual person, health care professionals, health insurance providers, society and politics. How could we pay for this?
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March 28, 2025 at 12:55 PM
8.) Our current health care setting fails to prioritize such measures. What could be done to improve the situation? On the level of the individual person, health care professionals, health insurance providers, society and politics. How could we pay for this?
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