Bjarni V. Halldórsson
@bvhalldorsson.bsky.social
Head of Sequence Analysis, deCODE genetics. Associate Professor, Biomedical Engineering, Reykjavik University.
January 22, 2025 at 4:13 PM
NCOs are substantially more prominent than COs in centromeres, possibly to avoid large-scale genomic changes that may cause aneuploidy. NCOs are more common in genes, presumably to preserve coding integrity.
January 22, 2025 at 4:13 PM
NCOs are substantially more prominent than COs in centromeres, possibly to avoid large-scale genomic changes that may cause aneuploidy. NCOs are more common in genes, presumably to preserve coding integrity.
Recombination, primarily NCO, is responsible for 1.8% (95% CI: 1.3-2.3) and 11.3% (95% CI: 9.0-13.6) of paternal and maternal de novo mutations (DNMs), respectively, and may drive the increase in DNMs with maternal age
January 22, 2025 at 4:13 PM
Recombination, primarily NCO, is responsible for 1.8% (95% CI: 1.3-2.3) and 11.3% (95% CI: 9.0-13.6) of paternal and maternal de novo mutations (DNMs), respectively, and may drive the increase in DNMs with maternal age
We show that the number of NCOs increases rapidly with the age of the mother in a non-regulated fashion.
January 22, 2025 at 4:13 PM
We show that the number of NCOs increases rapidly with the age of the mother in a non-regulated fashion.
Recombination occurs in two forms, crossover (CO) and non-crossover (NCO). NCOs are more diffcult to detect and have until now not been included in recombination maps.
January 22, 2025 at 4:13 PM
Recombination occurs in two forms, crossover (CO) and non-crossover (NCO). NCOs are more diffcult to detect and have until now not been included in recombination maps.