How does AI.zymes work?

AI.zymes combines the best of🛠️#Rosetta,🧠#ProteinMPNN,🔮#ESMFold, and⚡#FieldTools in rounds of design and selection.

Unlike other enzyme design algorithms, AI.zymes can directly target biocatalytic properties — not just folding or stability.

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🚨Out now in Angewandte Chemie:

AI.zymes - A modular platform for evolutionary enzyme design.

AI.zymes integrates established and emerging bioengineering tools into a coherent pipeline for #enzymedesign.

📄Paper: doi.org/10.1002/anie...
💻GitHub: github.com/bunzela/AIzy...

🚨 Don’t miss your chance to apply for the 3 open PhD positions in our group!
🌞 Project I : #computationaldesign of #photoenzymes for solar-driven nitrogen reduction to ammonia.
🧪 Apply now! Screening starts April 1
🔗 mpg.de/24336572/phd...
@mpimicrobiomarburg.bsky.social @maxplanck.de

What’s next? What enzyme would YOU like to design? AI.zymes is ready to tackle new challenges with its modular, expandable framework.

Reach out to adrian.bunzel@bsse.ethz.ch to use AI.zymes to improve your favorite enzyme!🌍💬

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Experimental validation:
✅7.7x higher activity after evolutionary design.
✅thermostable and monomeric.
✅only 7 variants tested—a remarkable success rate!

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Designing electrostatic catalysis has been a long-standing challenge—until now.⚡

AI.zymes improves electrostatic catalysis NOT through design algorithms aimed at electrostatics - BUT by evolutionary selection to enrich stable proteins with beneficial electrostatics.💡

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What is AI.zymes?🤔 Using evolutionary design, AI.zymes combines the best of🛠️ #Rosetta🧬#ProteinMPNN🔍 #ESMFold and⚡ #FieldTools.

Unlike other algorithms, AI.zymes specifically optimizes biocatalytic properties.

And it’s highly modular, ready to expand as new tools emerge!

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🚨Preprint Alert!🚨

#ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔

Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️

biorxiv.org/content/10.1...
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