Ben Jackson
@btjackson.bsky.social
Cell biologist, metabolism enthusiast, incoming anesthesiologist at UCSF | Tri-I MD-PhD in NYC
Any pyruvate that is captured in the mitochondria comes at the expense of NAD+ regeneration in the cytosol by LDH; moreover, the conversion of glucose to pyruvate itself requires NAD+. How do cells that burn glucose-derived pyruvate efficiently regenerate their cytosolic NAD+? 3/
April 28, 2025 at 2:28 PM
Any pyruvate that is captured in the mitochondria comes at the expense of NAD+ regeneration in the cytosol by LDH; moreover, the conversion of glucose to pyruvate itself requires NAD+. How do cells that burn glucose-derived pyruvate efficiently regenerate their cytosolic NAD+? 3/