Sabine D. Brookman-May, MD, FEBU🚴♀️🚴♀️🚴♀️🏔️⛷️⛰️
@brookmans76.bsky.social
Professor of Urology - Urologic Oncology, Sports Medicine @LMU Munich
Senior VP Therapeutic Area Head Urologic Oncology, Aura Biosciences, Boston, MA (former J&J R&D)
Avid Reader, Hiker, Skier, Enthusiastic Cyclist 🚴♀️🚴♀️🚴♀️ and Wine Grower in Mallorca 🍇🍷
Senior VP Therapeutic Area Head Urologic Oncology, Aura Biosciences, Boston, MA (former J&J R&D)
Avid Reader, Hiker, Skier, Enthusiastic Cyclist 🚴♀️🚴♀️🚴♀️ and Wine Grower in Mallorca 🍇🍷
Some contrast to my usual oncology research work - but with a good focus on my #urology background. Talked to @gqmagazine.bsky.social Germany and GoSping.de about #STI #SexuallyTransmittedDiseases and how important #awareness and #treatment is. Great interview!
👉 www.gq-magazin.de/artikel/6-my...
👉 www.gq-magazin.de/artikel/6-my...
March 13, 2025 at 6:04 PM
Some contrast to my usual oncology research work - but with a good focus on my #urology background. Talked to @gqmagazine.bsky.social Germany and GoSping.de about #STI #SexuallyTransmittedDiseases and how important #awareness and #treatment is. Great interview!
👉 www.gq-magazin.de/artikel/6-my...
👉 www.gq-magazin.de/artikel/6-my...
On my way back home from #ascoGU25 Great discussion yesterday by @ERPlimackMD of #CheckMate 274 / #NIAGARA in the context of perioperative + adjuvant immunotherapy in #bladdercancer @oncodaily.bsky.social @oncoalert.bsky.social
February 15, 2025 at 5:23 PM
On my way back home from #ascoGU25 Great discussion yesterday by @ERPlimackMD of #CheckMate 274 / #NIAGARA in the context of perioperative + adjuvant immunotherapy in #bladdercancer @oncodaily.bsky.social @oncoalert.bsky.social
Updated analysis with additional FU of EV 302 EV+P in 1st line advanced #BladderCancer
✅ PFS & OS benefit in all groups
✅ Benefit in cisplatin eligible/ineligible
✅ Safety consistent with prior analysis
✅ mDOR close to 2 years #ascoGU25 @oncodaily.bsky.social
✅ PFS & OS benefit in all groups
✅ Benefit in cisplatin eligible/ineligible
✅ Safety consistent with prior analysis
✅ mDOR close to 2 years #ascoGU25 @oncodaily.bsky.social
February 15, 2025 at 5:21 PM
Updated analysis with additional FU of EV 302 EV+P in 1st line advanced #BladderCancer
✅ PFS & OS benefit in all groups
✅ Benefit in cisplatin eligible/ineligible
✅ Safety consistent with prior analysis
✅ mDOR close to 2 years #ascoGU25 @oncodaily.bsky.social
✅ PFS & OS benefit in all groups
✅ Benefit in cisplatin eligible/ineligible
✅ Safety consistent with prior analysis
✅ mDOR close to 2 years #ascoGU25 @oncodaily.bsky.social
Great weekend with a 12 1/3 hrs indoor cycling race 🚴♂️🚴♀️🚴🚴 Great start into the 2025 season and after recovering from 2024 pelvic fracture
February 3, 2025 at 6:32 AM
Great weekend with a 12 1/3 hrs indoor cycling race 🚴♂️🚴♀️🚴🚴 Great start into the 2025 season and after recovering from 2024 pelvic fracture
Just a beautiful weekend! As it should be…
January 25, 2025 at 4:23 PM
Just a beautiful weekend! As it should be…
Rethinking #ProstateBiopsy protocols:
A systematic review (23 studies, 12,324 pts) shows that #AntibioticProhylaxis can safely be omitted in transperineal bx 💉w/o elevating infectious risks 🧫
#ProstateCancer #Urology #AntibioticStewardship @lucacindolo.bsky.social
👉 www.nature.com/articles/s41...
A systematic review (23 studies, 12,324 pts) shows that #AntibioticProhylaxis can safely be omitted in transperineal bx 💉w/o elevating infectious risks 🧫
#ProstateCancer #Urology #AntibioticStewardship @lucacindolo.bsky.social
👉 www.nature.com/articles/s41...
January 12, 2025 at 9:44 AM
Rethinking #ProstateBiopsy protocols:
A systematic review (23 studies, 12,324 pts) shows that #AntibioticProhylaxis can safely be omitted in transperineal bx 💉w/o elevating infectious risks 🧫
#ProstateCancer #Urology #AntibioticStewardship @lucacindolo.bsky.social
👉 www.nature.com/articles/s41...
A systematic review (23 studies, 12,324 pts) shows that #AntibioticProhylaxis can safely be omitted in transperineal bx 💉w/o elevating infectious risks 🧫
#ProstateCancer #Urology #AntibioticStewardship @lucacindolo.bsky.social
👉 www.nature.com/articles/s41...
New meta-analysis shows #PDE5 inhibitors, like tadalafil & sildenafil, may modestly reduce HbA1c levels in diabetes, with long-acting inhibitors having a greater impact. Promising dual benefit for managing diabetes & #erectiledysfunction. #Diabetes #PDE5 #HbA1c
January 6, 2025 at 10:47 AM
New meta-analysis shows #PDE5 inhibitors, like tadalafil & sildenafil, may modestly reduce HbA1c levels in diabetes, with long-acting inhibitors having a greater impact. Promising dual benefit for managing diabetes & #erectiledysfunction. #Diabetes #PDE5 #HbA1c
Exercise improves quality of life for #ProstateCancer patients. Our latest systematic review shows combined resistance and aerobic training reduces fatigue, enhances mental and sexual health, and boosts fitness. Resistance training also improves body composition #ProstateCancer #PhysicalExercise
December 23, 2024 at 8:39 PM
Exercise improves quality of life for #ProstateCancer patients. Our latest systematic review shows combined resistance and aerobic training reduces fatigue, enhances mental and sexual health, and boosts fitness. Resistance training also improves body composition #ProstateCancer #PhysicalExercise
Feels good to realize I am back on @gozwift.bsky.social @zwiftrides.bsky.social to get up to 4 jerseys in one training. Rehab is now definitely over after my pelvic fracture 3 months ago #Roadbike #Cycling Back to real training and rides!
December 21, 2024 at 6:31 PM
Feels good to realize I am back on @gozwift.bsky.social @zwiftrides.bsky.social to get up to 4 jerseys in one training. Rehab is now definitely over after my pelvic fracture 3 months ago #Roadbike #Cycling Back to real training and rides!
December 8, 2024 at 2:08 AM
Impressive results: Ph 2 trial: BCG + gemcitabine in BCG-exposed #NMIBC (HG Ta/T1/CIS)
✅ 6 & 12 mo CR: 94% & 81%
✅ 6, 12 & 18 mo HG-RFS: 97%, 85%, 76%
✅ 2 Gr AEs (UTI, pneumonitis). No Gr 4,5 AEs
Phase 3 trial vs BCG will follow #SUO24 #BladderCancer @oncodaily.bsky.social
✅ 6 & 12 mo CR: 94% & 81%
✅ 6, 12 & 18 mo HG-RFS: 97%, 85%, 76%
✅ 2 Gr AEs (UTI, pneumonitis). No Gr 4,5 AEs
Phase 3 trial vs BCG will follow #SUO24 #BladderCancer @oncodaily.bsky.social
December 6, 2024 at 11:55 PM
Impressive results: Ph 2 trial: BCG + gemcitabine in BCG-exposed #NMIBC (HG Ta/T1/CIS)
✅ 6 & 12 mo CR: 94% & 81%
✅ 6, 12 & 18 mo HG-RFS: 97%, 85%, 76%
✅ 2 Gr AEs (UTI, pneumonitis). No Gr 4,5 AEs
Phase 3 trial vs BCG will follow #SUO24 #BladderCancer @oncodaily.bsky.social
✅ 6 & 12 mo CR: 94% & 81%
✅ 6, 12 & 18 mo HG-RFS: 97%, 85%, 76%
✅ 2 Gr AEs (UTI, pneumonitis). No Gr 4,5 AEs
Phase 3 trial vs BCG will follow #SUO24 #BladderCancer @oncodaily.bsky.social
He was and is an icon and legend
#VirgilAbloh
Thank you @oncodaily.bsky.social for remembering him
I can also recommend reading his Abloh-isms
#VirgilAbloh
Thank you @oncodaily.bsky.social for remembering him
I can also recommend reading his Abloh-isms
November 30, 2024 at 11:02 PM
He was and is an icon and legend
#VirgilAbloh
Thank you @oncodaily.bsky.social for remembering him
I can also recommend reading his Abloh-isms
#VirgilAbloh
Thank you @oncodaily.bsky.social for remembering him
I can also recommend reading his Abloh-isms
Interesting paper showing that #antibiotics may reduce cancer risk by depleting gut microbiota metabolizing nitrosamines #BladderCancer #Microbiome
But (not discussed in the paper):
🚩AB can also disrupt beneficial microbial functions
🚩Increase cancer risk
🚩Negatively impact outcomes of IO therapy
But (not discussed in the paper):
🚩AB can also disrupt beneficial microbial functions
🚩Increase cancer risk
🚩Negatively impact outcomes of IO therapy
November 26, 2024 at 5:18 PM
Interesting paper showing that #antibiotics may reduce cancer risk by depleting gut microbiota metabolizing nitrosamines #BladderCancer #Microbiome
But (not discussed in the paper):
🚩AB can also disrupt beneficial microbial functions
🚩Increase cancer risk
🚩Negatively impact outcomes of IO therapy
But (not discussed in the paper):
🚩AB can also disrupt beneficial microbial functions
🚩Increase cancer risk
🚩Negatively impact outcomes of IO therapy
November 23, 2024 at 11:05 AM
EAU Talent Incubator Module 4 in Berlin was a great one again! Active participants, great topics #Policy #Innovation important for academic and non-academic urologists, and perfect network opportunity @uroweb.bsky.social @jlvasquez82.bsky.social
November 23, 2024 at 11:05 AM
EAU Talent Incubator Module 4 in Berlin was a great one again! Active participants, great topics #Policy #Innovation important for academic and non-academic urologists, and perfect network opportunity @uroweb.bsky.social @jlvasquez82.bsky.social
Just out: Our multicenter study comparing Uromonitor® DNA assay to #UrineCytology for #BladderCancer
✅ TERT & FGFR-3 mutations strongly predict UCB
❌ 93.3% specificity, but 49.3% sensitivity only
❌ KRAS mutations lacked predictive value.
🤔 The quest for optimal non-invasive #biomarker continues
✅ TERT & FGFR-3 mutations strongly predict UCB
❌ 93.3% specificity, but 49.3% sensitivity only
❌ KRAS mutations lacked predictive value.
🤔 The quest for optimal non-invasive #biomarker continues
November 20, 2024 at 11:04 PM
Just out: Our multicenter study comparing Uromonitor® DNA assay to #UrineCytology for #BladderCancer
✅ TERT & FGFR-3 mutations strongly predict UCB
❌ 93.3% specificity, but 49.3% sensitivity only
❌ KRAS mutations lacked predictive value.
🤔 The quest for optimal non-invasive #biomarker continues
✅ TERT & FGFR-3 mutations strongly predict UCB
❌ 93.3% specificity, but 49.3% sensitivity only
❌ KRAS mutations lacked predictive value.
🤔 The quest for optimal non-invasive #biomarker continues
Sunrise 2 was recently stopped based on the IDMC recommendation as TAR-200 + Cetrelimab didn't show superiority over chemoradiation. But SR4 still ongoing. And T0 rates (also of other treatments) raise the hope for potential #bladdersparing approaches! #TAR200 #MIBC
November 19, 2024 at 10:31 AM
Sunrise 2 was recently stopped based on the IDMC recommendation as TAR-200 + Cetrelimab didn't show superiority over chemoradiation. But SR4 still ongoing. And T0 rates (also of other treatments) raise the hope for potential #bladdersparing approaches! #TAR200 #MIBC
Interesting what ChatGPT creates! I just tried the same and it looks like this. Surprising also that I am male:-) and that I drink tea instead of coffee
November 18, 2024 at 8:49 PM
Interesting what ChatGPT creates! I just tried the same and it looks like this. Surprising also that I am male:-) and that I drink tea instead of coffee
Coming back from Boston last Friday still with crutches due to my #Roadbike accident + pelvic fracture, I decided to get rid of them now and start getting my fitness back on @gozwift.bsky.social @gozwift.bsky.social
7 weeks of muscle and power loss are enough💪🚴♀️🚴♀️🚴♀️
7 weeks of muscle and power loss are enough💪🚴♀️🚴♀️🚴♀️
November 18, 2024 at 12:27 PM
Coming back from Boston last Friday still with crutches due to my #Roadbike accident + pelvic fracture, I decided to get rid of them now and start getting my fitness back on @gozwift.bsky.social @gozwift.bsky.social
7 weeks of muscle and power loss are enough💪🚴♀️🚴♀️🚴♀️
7 weeks of muscle and power loss are enough💪🚴♀️🚴♀️🚴♀️
Looks like we need an update for this position statement to include #BlueSky
@bsky.app @mariajribal.bsky.social @giannarini.bsky.social @uroweb.bsky.social
#UroSoMe
@bsky.app @mariajribal.bsky.social @giannarini.bsky.social @uroweb.bsky.social
#UroSoMe
November 18, 2024 at 12:22 PM
Looks like we need an update for this position statement to include #BlueSky
@bsky.app @mariajribal.bsky.social @giannarini.bsky.social @uroweb.bsky.social
#UroSoMe
@bsky.app @mariajribal.bsky.social @giannarini.bsky.social @uroweb.bsky.social
#UroSoMe
Great lecture for a Sunday! Vladimir #Sorokin’s Tagebuch eines Meisterkochs: In 2037 the society no longer values #literature. A chef literally turns #books📗 into dishes + creates meals inspired by their essence, eg, sturgeon on Dostojewski’s The Idiot. Dark humor paired with a provocative premise
November 17, 2024 at 8:55 PM
Great lecture for a Sunday! Vladimir #Sorokin’s Tagebuch eines Meisterkochs: In 2037 the society no longer values #literature. A chef literally turns #books📗 into dishes + creates meals inspired by their essence, eg, sturgeon on Dostojewski’s The Idiot. Dark humor paired with a provocative premise
Looks like there is an additional benefit related to high-intensity aerobic exercise training compared to afternoon training in improving the health of individuals with metabolic syndrome #AerobicExercise #MetabolicSyndrome #HighIntensity
November 16, 2024 at 4:35 PM
Looks like there is an additional benefit related to high-intensity aerobic exercise training compared to afternoon training in improving the health of individuals with metabolic syndrome #AerobicExercise #MetabolicSyndrome #HighIntensity
November 16, 2024 at 12:42 PM