Brian O. Bachmann
@brianobachmann.bsky.social
Prof. Chemical Biology, PI the Vanderbilt Laboratory for Biosynthetic Studies. Posting natural product tilted human chemical biology, biosynthesis, synthetic biology, and discovery. He/him.
The Discovery of Complex Heterocycles from Millipede Secretions, fantastic work from the Mevers group that I saw the full story from at SERMACS this week.
pubs.acs.org/doi/10.1021/...
#secmet
pubs.acs.org/doi/10.1021/...
#secmet
October 28, 2025 at 4:56 PM
The Discovery of Complex Heterocycles from Millipede Secretions, fantastic work from the Mevers group that I saw the full story from at SERMACS this week.
pubs.acs.org/doi/10.1021/...
#secmet
pubs.acs.org/doi/10.1021/...
#secmet
Dracomicins, Hybrid Oligosaccharide–Nonribosomal Peptide Antibiotics from Amycolatopsis Species
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
June 13, 2025 at 9:40 PM
Dracomicins, Hybrid Oligosaccharide–Nonribosomal Peptide Antibiotics from Amycolatopsis Species
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
From the Jensen lab: Pattern-based genome mining guides discovery of the antibiotic indanopyrrole A from a marine streptomycete
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2024 at 7:10 PM
From the Jensen lab: Pattern-based genome mining guides discovery of the antibiotic indanopyrrole A from a marine streptomycete
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
👀 “S. coelicolor encodes three “umbrella particles” with distinct toxin and lectin composition, and supernatant containing these toxins specifically and potently inhibits the growth of select Streptomyces species.” Not #secmet, but cool S.coel technology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 12, 2023 at 12:28 AM
👀 “S. coelicolor encodes three “umbrella particles” with distinct toxin and lectin composition, and supernatant containing these toxins specifically and potently inhibits the growth of select Streptomyces species.” Not #secmet, but cool S.coel technology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Wow! A beautiful hexacyclic sesterterpene via in vitro reaction with a cloned terpene cyclase from Streptomyces subrutilus #secmet
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
October 30, 2023 at 7:08 PM
Wow! A beautiful hexacyclic sesterterpene via in vitro reaction with a cloned terpene cyclase from Streptomyces subrutilus #secmet
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Structure and Function of the alpha-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase #secmet
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
October 18, 2023 at 3:56 PM
Structure and Function of the alpha-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase #secmet
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
#secmet folks : a teach-in in honor of Chris Walsh. All students and post-docs encouraged to attend. This is an outstanding speaker list inspired a great scientist & teacher.
October 15, 2023 at 1:36 PM
#secmet folks : a teach-in in honor of Chris Walsh. All students and post-docs encouraged to attend. This is an outstanding speaker list inspired a great scientist & teacher.
Cave chemistry collection with grad students.
September 27, 2023 at 10:31 PM
Cave chemistry collection with grad students.
Novel Biocatalysts from Specialized Metabolism from Hertweck and Co.
Chemsky 🧪
onlinelibrary.wiley.com/doi/abs/10.1...
Chemsky 🧪
onlinelibrary.wiley.com/doi/abs/10.1...
September 27, 2023 at 2:50 PM
Novel Biocatalysts from Specialized Metabolism from Hertweck and Co.
Chemsky 🧪
onlinelibrary.wiley.com/doi/abs/10.1...
Chemsky 🧪
onlinelibrary.wiley.com/doi/abs/10.1...
Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. Production of the NRPS BpsA from Streptomyces lavendulae and the RXP producer Xenorhabdus KJ12.1
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
September 20, 2023 at 3:46 PM
Cell-Free Synthesis of Natural Compounds from Genomic DNA of Biosynthetic Gene Clusters. Production of the NRPS BpsA from Streptomyces lavendulae and the RXP producer Xenorhabdus KJ12.1
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
August 24, 2023 at 1:24 PM
Global warming + Prometheus, a toxic combination to nature, perhaps a lesson for today? 🧪 https://www.science.org/doi/10.1126/science.abo3594
August 21, 2023 at 1:52 PM
Global warming + Prometheus, a toxic combination to nature, perhaps a lesson for today? 🧪 https://www.science.org/doi/10.1126/science.abo3594
Breaking news: Actual 'evil genius' plan to blot out the sun! 🧪
https://www.pnas.org/doi/10.1073/pnas.2307434120
https://www.pnas.org/doi/10.1073/pnas.2307434120
August 7, 2023 at 1:10 PM
Breaking news: Actual 'evil genius' plan to blot out the sun! 🧪
https://www.pnas.org/doi/10.1073/pnas.2307434120
https://www.pnas.org/doi/10.1073/pnas.2307434120
Embarrassed I did not know, and delighted to learn, that there are over 300 organoarsenic natural products. Bisenarsan is the first actinomycete-derived arsenic-containing secondary metabolite to be characterized. 🧪
https://pubs.acs.org/doi/10.1021/jacs.3c04978
https://pubs.acs.org/doi/10.1021/jacs.3c04978
August 6, 2023 at 4:04 PM
Embarrassed I did not know, and delighted to learn, that there are over 300 organoarsenic natural products. Bisenarsan is the first actinomycete-derived arsenic-containing secondary metabolite to be characterized. 🧪
https://pubs.acs.org/doi/10.1021/jacs.3c04978
https://pubs.acs.org/doi/10.1021/jacs.3c04978