1960 ASBs are strong candidates for causally altering human traits: they’re in ChIP-Seq peaks & strengthen/weaken TF motifs in agreement with TF affinity change & are evolutionarily conserved & enriched for trait associations & eQTLs
Fab collaboration w/ Breeshey Roskams-Hieter & Øyvind Almelid 2/2

What DNA variants alter transcription factor (TF) binding affinity? Here, we describe a new workflow baal-nf. We used it to trawl through 6017 ChIP-Seq data sets for 558 TFs and 46 genotyped cell lines, finding 298,783 allele-specific binding sites (ASBs).
www.biorxiv.org/content/10.1...
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