📖 Read the full preprint: doi.org/10.1101/2025...
AI-generated podcast at

notebooklm.google.com/notebook/b28...

and my Mentors, @frederic-rousseau.bsky.social and Joost Schymkowitz at the
@vib-switch-lab.bsky.social
,
@cbdresearch.bsky.social
who made this work possible.

💬 I’m grateful for the help of an incredible team of collaborators, Senthil Kumar Thangaraj
@wagnerjessica.bsky.social

@rodrigoagallardo.bsky.social
Gabriele Orlando Matthias De Vleeschouwer Jillian Madine
@nlouros.bsky.social

@jonasneher.bsky.social

📌 Key Takeaways:

Medin co-aggregation enables the assembly of Aβ40 into fibrils structurally similar to those of Aβ42.

Cryo-EM reconstructions reveal a novel F-shaped topology of Aβ40
Adds molecular support to the idea that medin contributes to AD via fibril cross-seeding.

This suggests a new mechanism by which medin may exacerbate cerebral amyloid angiopathy and Alzheimer’s progression.