Adam Braithwaite
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braithwaiteat.bsky.social
Adam Braithwaite
@braithwaiteat.bsky.social
410 followers 540 following 9 posts
Senior Scientist, Bioinformatics @ Gilead Sciences | Bioinformatics | Computational biology | Fibrosis | Immunology | Cardiovascular disease

https://scholar.google.co.uk/citations?hl=en&user=QgA-ngcAAAAJ&view_op=list_works&sortby=pubdate
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braithwaiteat.bsky.social
In experiments with mixed immune cells (e.g. from blood), stimulation can induce downstream effects in non-target cells. We compared signalling by ligand-receptor analysis of single cell RNA profiles from 150K immune cells treated with 11 different simulations. doi.org/10.1101/2025...
🧪🧬🖥️ #immunosky
In experiments with mixed immune cells (e.g. from blood), stimulation can induce downstream effects in non-target cells. We compared signalling by ligand-receptor analysis of single cell RNA profiles from 150K immune cells treated with 11 different simulations. The top left panel shows an overall comparison of the signalling interactions within each stimulation condition. The top right panel highlights three distinct groups of stimulations and the signalling specific to them. The bottom panel highlights key interactions from the IFNa and TGFb1 conditions across samples and downstream activity in target cells.
July 19, 2025 at 9:59 PM
braithwaiteat.bsky.social
We compared the single cell transcriptome profiles of 150K immune cells treated with 11 different simulations to multiple inflammatory disease profiles. This open resource can help in selecting more disease-relevant in vitro conditions for immune cells. doi.org/10.1101/2025...
🧪🧬🖥️ #immunosky #medsky
To help selection of the most appropriate in vitro stimulations to model diseases, we also compared the single cell transcriptome profiles of 150K immune cells treated with 11 different simulations to multiple inflammatory disease gene expression profiles. The top plots show the similarity between in vitro stimulations of human blood cells, and bulk RNA sequencing profiles of the blood cells from rheumatoid arthritis or systemic lupus erythematous. The bottom left plot shows clustering of single cell RNA profiles from systemic lupus erythematous, with the bottom right plot highlighting similarities in simulated immune cells.
July 6, 2025 at 11:52 AM
braithwaiteat.bsky.social
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
July 3, 2025 at 3:39 PM