@braincancerlab.bsky.social
Interdisciplinary brain cancer lab headed by @sarahannbest.bsky.social, @SaskiaFreytag.bsky.social, and @jimwhittle.bsky.social studying brain cancer at the @WEHI-research.bsky.social
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Yes! Our collaborators @Florey performed patch clamp electrophysiology on fresh tissue pre- and post-treatment and found a reduction in synaptic activity.
This is consistent with recently published results in a clinical trial of another mIDH inhibitor, where patients reported fewer seizures!
7/8
This is consistent with recently published results in a clinical trial of another mIDH inhibitor, where patients reported fewer seizures!
7/8
August 22, 2025 at 9:51 PM
Yes! Our collaborators @Florey performed patch clamp electrophysiology on fresh tissue pre- and post-treatment and found a reduction in synaptic activity.
This is consistent with recently published results in a clinical trial of another mIDH inhibitor, where patients reported fewer seizures!
7/8
This is consistent with recently published results in a clinical trial of another mIDH inhibitor, where patients reported fewer seizures!
7/8
Spatially, neurons in the leading edge of tumours seemed to have a decrease in synaptic signalling pathway expression.
Could the mIDH inhibitor, or the resulting reduction in the metabolite 2-HG, be impacting neuronal activity?
6/8
Could the mIDH inhibitor, or the resulting reduction in the metabolite 2-HG, be impacting neuronal activity?
6/8
August 22, 2025 at 9:51 PM
Spatially, neurons in the leading edge of tumours seemed to have a decrease in synaptic signalling pathway expression.
Could the mIDH inhibitor, or the resulting reduction in the metabolite 2-HG, be impacting neuronal activity?
6/8
Could the mIDH inhibitor, or the resulting reduction in the metabolite 2-HG, be impacting neuronal activity?
6/8
Next: what happens transcriptionally when mIDH is inhibited? @montanaspiteri.bsky.social investigated the impacts on a single-cell level and found that the progenitor population became less differentiated following treatment.
5/8
5/8
August 22, 2025 at 9:51 PM
Next: what happens transcriptionally when mIDH is inhibited? @montanaspiteri.bsky.social investigated the impacts on a single-cell level and found that the progenitor population became less differentiated following treatment.
5/8
5/8
Our first answer: the drug gets in! We can see from the spatial distribution of metabolite biomarker 2-HG that mIDH treatment markedly reduces 2-HG abundance throughout the tumour using spatial metabolomics with @sai22vinod.bsky.social and colleagues.
4/8
4/8
August 22, 2025 at 9:51 PM
Our first answer: the drug gets in! We can see from the spatial distribution of metabolite biomarker 2-HG that mIDH treatment markedly reduces 2-HG abundance throughout the tumour using spatial metabolomics with @sai22vinod.bsky.social and colleagues.
4/8
4/8
IDH-mutant glioma patients underwent a pre-treatment biopsy followed by one cycle of treatment and surgical resection of tumour.
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
August 22, 2025 at 9:51 PM
IDH-mutant glioma patients underwent a pre-treatment biopsy followed by one cycle of treatment and surgical resection of tumour.
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
Next: what happens transcriptionally when mIDH is inhibited? @montanaspiteri.bsky.social investigated the impacts on a single-cell level and found that the progenitor population became less differentiated following treatment.
5/8
5/8
August 22, 2025 at 9:42 PM
Next: what happens transcriptionally when mIDH is inhibited? @montanaspiteri.bsky.social investigated the impacts on a single-cell level and found that the progenitor population became less differentiated following treatment.
5/8
5/8
Our first answer: the drug gets in! We can see from the spatial distribution of metabolite biomarker 2-HG that mIDH treatment markedly reduces 2-HG abundance throughout the tumour using spatial metabolomics with @sai22vinod.bsky.social and colleagues.
4/8
4/8
August 22, 2025 at 9:42 PM
Our first answer: the drug gets in! We can see from the spatial distribution of metabolite biomarker 2-HG that mIDH treatment markedly reduces 2-HG abundance throughout the tumour using spatial metabolomics with @sai22vinod.bsky.social and colleagues.
4/8
4/8
IDH-mutant glioma patients underwent a pre-treatment biopsy followed by one cycle of treatment and surgical resection of tumour.
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
August 22, 2025 at 9:42 PM
IDH-mutant glioma patients underwent a pre-treatment biopsy followed by one cycle of treatment and surgical resection of tumour.
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8