Sheerazed Boulkroun
boulkrounshee.bsky.social
Sheerazed Boulkroun
@boulkrounshee.bsky.social
From adrenal physiology to cardiometabolic consequences of adrenal dysfunction
5/5
@straversallard.bsky.social, Stéphanie Baron, David Penton Ribas, @fabiofrosa.bsky.social, Maria-Christina Zennaro
March 17, 2025 at 9:41 PM
4/5
Thank you to all the co-authors and collaborators !

Bakhta Fedlaoui, Teresa Cosentino, Zeina Al Sayed, Rita Alexandre Coelho, Isabelle Giscos-Douriez, Nicolò Faedda, @mayfayad.bsky.social, Jean-Sébastien Hulot, Chris Magnus, Scott Sternson
March 17, 2025 at 9:39 PM
3/5
Applying this chemogenetic approach could also enable the development of a new inducible mouse model of primary aldosteronism, providing a valuable tool for dissecting the mechanisms underlying aldosterone producing adenoma development and for evaluating new therapeutic strategies.
March 17, 2025 at 9:38 PM
2/5
This innovative model could be used to test the molecular impact of new treatments for primary aldosteronism in vitro.
March 17, 2025 at 9:37 PM
1/5
We demonstrated that increased expression of CYP11B2 and stimulation of the mineralocorticoid biosynthesis pathway are associated with a decrease of cell proliferation and an increase of apoptosis, indicating that additional events may be required for the development of APA.
March 17, 2025 at 9:37 PM
1/5
We demonstrated that increased expression of CYP11B2 and stimulation of the mineralocorticoid biosynthesis pathway are associated with a decrease of cell proliferation and an increase of apoptosis, indicating that additional events may be required for the development of APA.
March 17, 2025 at 9:35 PM
Congrats!
November 29, 2024 at 10:36 PM
Merci!
Je decouvre
September 23, 2023 at 7:41 PM