boudkerlab.bsky.social
@boudkerlab.bsky.social
A beautiful collaboration with the Accardi and Robertson labs is out! Using a battery of structural/biophysical techniques, we show that CLC-ec1 undergoes large-scale, pH-dependent structural changes - we propose this underlies common gating. Read below!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of pH-dependent activation in a CLC transporter - Nature Structural & Molecular Bio...
This study reveals the mechanism by which protons gate a CLC-type Cl−/H+ exchanger. The authors show that pH-dependent concerted structural rearrangements open the H+ pathway, which allosterically e...
www.nature.com
January 27, 2024 at 6:31 PM
A beautiful collaboration with the Accardi and Robertson labs is out! Using a battery of structural/biophysical techniques, we show that CLC-ec1 undergoes large-scale, pH-dependent structural changes - we propose this underlies common gating. Read below!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by boudkerlab.bsky.social
Incredible analysis on the emergence of new transport function in sodium- and proton-coupled transporters using ancestral sequence reconstruction, cryo-EM, and activity assays. Turns out the proposed ancestors do not need to use cations at all!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 8, 2023 at 7:02 AM
Incredible analysis on the emergence of new transport function in sodium- and proton-coupled transporters using ancestral sequence reconstruction, cryo-EM, and activity assays. Turns out the proposed ancestors do not need to use cations at all!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...