Boreaus Institute
@boreaus-institute.bsky.social
Founder & technologist. My mission: to pioneer the pro-health span revolution. I'm leveraging cutting-edge science to build a healthier future.
A warning for #ALS trials!
The new Cell study on the failed BIIB078 ASO (for C9orf72 gene) shows the drug hit the CNS, but didn't clear the toxic G4C2 RNA in brain tissue, thus, toxic pathologies (DPRs, pTDP-43) remained.
Significance: CSF biomarkers were misleading—they didn't match the brain!
The new Cell study on the failed BIIB078 ASO (for C9orf72 gene) shows the drug hit the CNS, but didn't clear the toxic G4C2 RNA in brain tissue, thus, toxic pathologies (DPRs, pTDP-43) remained.
Significance: CSF biomarkers were misleading—they didn't match the brain!
November 17, 2025 at 9:08 PM
A warning for #ALS trials!
The new Cell study on the failed BIIB078 ASO (for C9orf72 gene) shows the drug hit the CNS, but didn't clear the toxic G4C2 RNA in brain tissue, thus, toxic pathologies (DPRs, pTDP-43) remained.
Significance: CSF biomarkers were misleading—they didn't match the brain!
The new Cell study on the failed BIIB078 ASO (for C9orf72 gene) shows the drug hit the CNS, but didn't clear the toxic G4C2 RNA in brain tissue, thus, toxic pathologies (DPRs, pTDP-43) remained.
Significance: CSF biomarkers were misleading—they didn't match the brain!
A felon, a pimp, a scourge to this country.
November 15, 2025 at 12:52 AM
A felon, a pimp, a scourge to this country.
Reposted by Boreaus Institute
Billionaires are now spending their fortunes not just to flee the planet they helped break, but to simultaneously achieve immortality.
It's the final, contemptible evolution of the god complex. When hoarding all the money on Earth isn't enough, you must also conquer death and space.
It's the final, contemptible evolution of the god complex. When hoarding all the money on Earth isn't enough, you must also conquer death and space.
November 15, 2025 at 12:35 AM
Billionaires are now spending their fortunes not just to flee the planet they helped break, but to simultaneously achieve immortality.
It's the final, contemptible evolution of the god complex. When hoarding all the money on Earth isn't enough, you must also conquer death and space.
It's the final, contemptible evolution of the god complex. When hoarding all the money on Earth isn't enough, you must also conquer death and space.
Remember that trendy "telomere-lengthening de-aging" supplement?
- Pure hype. No such "fountain of youth".
There's no solid human data it works, and forcing cells to become immortal is a spectacular way to get cancer.
True health span isn't in a bottle.
www.hopkinsmedicine.org/news/newsroo...
- Pure hype. No such "fountain of youth".
There's no solid human data it works, and forcing cells to become immortal is a spectacular way to get cancer.
True health span isn't in a bottle.
www.hopkinsmedicine.org/news/newsroo...
Long Telomeres, the Endcaps on DNA, Not the Fountain of Youth Once Thought — Scientists May Now Know Why
www.hopkinsmedicine.org
November 13, 2025 at 6:21 AM
Remember that trendy "telomere-lengthening de-aging" supplement?
- Pure hype. No such "fountain of youth".
There's no solid human data it works, and forcing cells to become immortal is a spectacular way to get cancer.
True health span isn't in a bottle.
www.hopkinsmedicine.org/news/newsroo...
- Pure hype. No such "fountain of youth".
There's no solid human data it works, and forcing cells to become immortal is a spectacular way to get cancer.
True health span isn't in a bottle.
www.hopkinsmedicine.org/news/newsroo...
We're fixing the wrong part of the heart!
A Science paper finds when heart muscle is weak, other cells (fibroblasts) panic, multiply, & strangle it stiff.
Value: Block one switch (p38) in them & the heart is saved. A new target!
Flaw: It's a genetic edit in mice that prevents, not reverses.
A Science paper finds when heart muscle is weak, other cells (fibroblasts) panic, multiply, & strangle it stiff.
Value: Block one switch (p38) in them & the heart is saved. A new target!
Flaw: It's a genetic edit in mice that prevents, not reverses.
November 13, 2025 at 5:59 AM
We're fixing the wrong part of the heart!
A Science paper finds when heart muscle is weak, other cells (fibroblasts) panic, multiply, & strangle it stiff.
Value: Block one switch (p38) in them & the heart is saved. A new target!
Flaw: It's a genetic edit in mice that prevents, not reverses.
A Science paper finds when heart muscle is weak, other cells (fibroblasts) panic, multiply, & strangle it stiff.
Value: Block one switch (p38) in them & the heart is saved. A new target!
Flaw: It's a genetic edit in mice that prevents, not reverses.
The American research dream is a lie. Politicians are gutting science budgets because they know the public doesn't care anymore. We're now creating a lost generation of scientists, training them for careers that are already dead. A national disgrace.
www.aamc.org/news/how-unc...
www.aamc.org/news/how-unc...
How uncertainty around cuts to scientific research is impacting the future biomedical research workforce
Researchers worry that temporary interruptions in PhD programs could have long-term implications for the biomedical sciences.
www.aamc.org
November 13, 2025 at 5:44 AM
The American research dream is a lie. Politicians are gutting science budgets because they know the public doesn't care anymore. We're now creating a lost generation of scientists, training them for careers that are already dead. A national disgrace.
www.aamc.org/news/how-unc...
www.aamc.org/news/how-unc...
A new Nature study is cool.
Upshot: An Alzheimer's gene (ABCA7) messes up fats in brain cells , breaking their batteries (mitochondria).
Value: They fixed it in a dish with a simple supplement (CDP-choline)! It even lowered amyloid gunk.
Flaw: This was in a lab dish, not a person. Big leap.
Upshot: An Alzheimer's gene (ABCA7) messes up fats in brain cells , breaking their batteries (mitochondria).
Value: They fixed it in a dish with a simple supplement (CDP-choline)! It even lowered amyloid gunk.
Flaw: This was in a lab dish, not a person. Big leap.
November 13, 2025 at 5:20 AM
A new Nature study is cool.
Upshot: An Alzheimer's gene (ABCA7) messes up fats in brain cells , breaking their batteries (mitochondria).
Value: They fixed it in a dish with a simple supplement (CDP-choline)! It even lowered amyloid gunk.
Flaw: This was in a lab dish, not a person. Big leap.
Upshot: An Alzheimer's gene (ABCA7) messes up fats in brain cells , breaking their batteries (mitochondria).
Value: They fixed it in a dish with a simple supplement (CDP-choline)! It even lowered amyloid gunk.
Flaw: This was in a lab dish, not a person. Big leap.