Riccardo Bocchi
@bocchiric.bsky.social
Developmental neurobiologist, interested in astrocytes. Based @neurogeneva http://bocchilab.ch
Thank you, Christian, for your valuable contribution!
August 3, 2025 at 12:39 PM
Thank you, Christian, for your valuable contribution!
Huge shoutout to first author @alanzhoujf.bsky.social 🙌 and all our fantastic collaborators — couldn’t have done it without such an amazing team work! 💥🧠 Thanks to the funding support from
@snsf.ch #Ambizione
@snsf.ch #Ambizione
July 31, 2025 at 7:17 AM
Huge shoutout to first author @alanzhoujf.bsky.social 🙌 and all our fantastic collaborators — couldn’t have done it without such an amazing team work! 💥🧠 Thanks to the funding support from
@snsf.ch #Ambizione
@snsf.ch #Ambizione
6/ 🧭 Want to explore the data yourself? Check out our interactive site where you can browse gene expression, subtype markers, lineage relationships, and spatial maps: 🌐 bocchilab.ch/Zhou_et_al_2...
July 31, 2025 at 7:17 AM
6/ 🧭 Want to explore the data yourself? Check out our interactive site where you can browse gene expression, subtype markers, lineage relationships, and spatial maps: 🌐 bocchilab.ch/Zhou_et_al_2...
5/ ⭐️ This study reshapes our understanding of how astrocyte diversity emerges during cortical development.
July 31, 2025 at 7:17 AM
5/ ⭐️ This study reshapes our understanding of how astrocyte diversity emerges during cortical development.
4/ Why does this matter?
Because astrocyte origin shapes astrocyte function.
Olig2-lineage astrocytes are synaptogenic — they promote synapse formation.
Knock out Olig2, and synaptic density drops.
Because astrocyte origin shapes astrocyte function.
Olig2-lineage astrocytes are synaptogenic — they promote synapse formation.
Knock out Olig2, and synaptic density drops.
July 31, 2025 at 7:17 AM
4/ Why does this matter?
Because astrocyte origin shapes astrocyte function.
Olig2-lineage astrocytes are synaptogenic — they promote synapse formation.
Knock out Olig2, and synaptic density drops.
Because astrocyte origin shapes astrocyte function.
Olig2-lineage astrocytes are synaptogenic — they promote synapse formation.
Knock out Olig2, and synaptic density drops.
3/ Lineage 1 🟦: Emx1⁺ radial glia → neurons first, astrocytes later.
Lineage 2 🟥: Emx1⁻ radial glia → few neurons, mostly astrocytes.
Each lineage gives rise to different astrocyte subtypes — with unique locations and functions.
Lineage 2 🟥: Emx1⁻ radial glia → few neurons, mostly astrocytes.
Each lineage gives rise to different astrocyte subtypes — with unique locations and functions.
July 31, 2025 at 7:17 AM
3/ Lineage 1 🟦: Emx1⁺ radial glia → neurons first, astrocytes later.
Lineage 2 🟥: Emx1⁻ radial glia → few neurons, mostly astrocytes.
Each lineage gives rise to different astrocyte subtypes — with unique locations and functions.
Lineage 2 🟥: Emx1⁻ radial glia → few neurons, mostly astrocytes.
Each lineage gives rise to different astrocyte subtypes — with unique locations and functions.
2/ Here is the twist 🧬.
Using high-throughput clonal tracing (TrackerSeq), we discovered that these subtypes originate from two molecularly distinct radial glia lineages.
Using high-throughput clonal tracing (TrackerSeq), we discovered that these subtypes originate from two molecularly distinct radial glia lineages.
July 31, 2025 at 7:17 AM
2/ Here is the twist 🧬.
Using high-throughput clonal tracing (TrackerSeq), we discovered that these subtypes originate from two molecularly distinct radial glia lineages.
Using high-throughput clonal tracing (TrackerSeq), we discovered that these subtypes originate from two molecularly distinct radial glia lineages.
1/ Not all astrocytes are created equal.
We mapped the molecular and spatial landscape of astrocytes in the mouse neocortex — and found five distinct subtypes, organized across cortical layers and white matter.
We mapped the molecular and spatial landscape of astrocytes in the mouse neocortex — and found five distinct subtypes, organized across cortical layers and white matter.
July 31, 2025 at 7:17 AM
1/ Not all astrocytes are created equal.
We mapped the molecular and spatial landscape of astrocytes in the mouse neocortex — and found five distinct subtypes, organized across cortical layers and white matter.
We mapped the molecular and spatial landscape of astrocytes in the mouse neocortex — and found five distinct subtypes, organized across cortical layers and white matter.
🌌 The journey into astrocyte diversity doesn’t stop here! Stay tuned for new insights into how their molecular and functional diversity originates during brain development. 🚀 A new story is coming soon—check out our bioRxiv preprint here: www.biorxiv.org/content/10.1...
Dual lineage origins of neocortical astrocytes
Astrocytes represent one of the most abundant cell types in the central nervous system, and play an essential role in nearly all aspects of brain functions[1][1]. Recent studies have challenged the no...
www.biorxiv.org
February 24, 2025 at 4:06 PM
🌌 The journey into astrocyte diversity doesn’t stop here! Stay tuned for new insights into how their molecular and functional diversity originates during brain development. 🚀 A new story is coming soon—check out our bioRxiv preprint here: www.biorxiv.org/content/10.1...
📊 Explore the single-cell RNA-seq data yourself: bocchilab.ch/Bocchi_et_al...
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter
bocchilab.ch
February 24, 2025 at 4:06 PM
📊 Explore the single-cell RNA-seq data yourself: bocchilab.ch/Bocchi_et_al...
💡 Why does this matter? This breakthrough unlocks new possibilities for 🛠️ brain repair, especially in conditions involving WM damage or degeneration. Understanding how these astrocytes support axons and drive myelination is key to tackling diseases like multiple sclerosis.
February 24, 2025 at 4:06 PM
💡 Why does this matter? This breakthrough unlocks new possibilities for 🛠️ brain repair, especially in conditions involving WM damage or degeneration. Understanding how these astrocytes support axons and drive myelination is key to tackling diseases like multiple sclerosis.
🔍 In the corpus callosum, WM astrocytes show a unique ability to proliferate—a feature completely absent in the cerebellar WM. This discovery highlights their region-specific roles in generating new astrocytes.
February 24, 2025 at 4:06 PM
🔍 In the corpus callosum, WM astrocytes show a unique ability to proliferate—a feature completely absent in the cerebellar WM. This discovery highlights their region-specific roles in generating new astrocytes.