Brandon Logeman
@blogeman.bsky.social
Assistant Professor at U of Kentucky Medicine 🐾
Functional Genomics of Neural Activity and Animal Behavior at the single cell level
🧬genes->🚥pathways->🧠circuits->🐭behavior
Functional Genomics of Neural Activity and Animal Behavior at the single cell level
🧬genes->🚥pathways->🧠circuits->🐭behavior
Likewise, another 2012 paper places calculates non-coding variants to be ~95%. However, this is examining lead variants, with ~41% of variants present in introns...which could be in LD with coding variants. 🧵
www-science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/...
www-science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/...
September 16, 2025 at 5:20 PM
Likewise, another 2012 paper places calculates non-coding variants to be ~95%. However, this is examining lead variants, with ~41% of variants present in introns...which could be in LD with coding variants. 🧵
www-science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/...
www-science-org.ezp-prod1.hul.harvard.edu/doi/10.1126/...
On the x-axis is every human gene, ranked by number of publications containing mention of the gene name. Lots left to discover...
February 15, 2025 at 3:57 PM
On the x-axis is every human gene, ranked by number of publications containing mention of the gene name. Lots left to discover...
Tail suspension test:
Mice don't like to be hung by their tails and vigorously try to escape. Immobility (decreased escape behavior) is viewed as depression-like behavior.
Mice don't like to be hung by their tails and vigorously try to escape. Immobility (decreased escape behavior) is viewed as depression-like behavior.
January 29, 2025 at 4:41 PM
Tail suspension test:
Mice don't like to be hung by their tails and vigorously try to escape. Immobility (decreased escape behavior) is viewed as depression-like behavior.
Mice don't like to be hung by their tails and vigorously try to escape. Immobility (decreased escape behavior) is viewed as depression-like behavior.
Y maze test:
The innate curiosity of rodents to explore previously unvisited areas is used to assess working memory...can the mouse remember which arms its previously visited?
The innate curiosity of rodents to explore previously unvisited areas is used to assess working memory...can the mouse remember which arms its previously visited?
January 29, 2025 at 4:41 PM
Y maze test:
The innate curiosity of rodents to explore previously unvisited areas is used to assess working memory...can the mouse remember which arms its previously visited?
The innate curiosity of rodents to explore previously unvisited areas is used to assess working memory...can the mouse remember which arms its previously visited?
Fox urine avoidance test:
Predator order, which is aversive, is placed on one side of the cage with mice able to freeing move about the cage.
Predator order, which is aversive, is placed on one side of the cage with mice able to freeing move about the cage.
January 29, 2025 at 4:41 PM
Fox urine avoidance test:
Predator order, which is aversive, is placed on one side of the cage with mice able to freeing move about the cage.
Predator order, which is aversive, is placed on one side of the cage with mice able to freeing move about the cage.
Novelty suppressed feeding:
Hungry mice must venture into an area with a bright light shinning down in order to obtain food.
Hungry mice must venture into an area with a bright light shinning down in order to obtain food.
January 29, 2025 at 4:41 PM
Novelty suppressed feeding:
Hungry mice must venture into an area with a bright light shinning down in order to obtain food.
Hungry mice must venture into an area with a bright light shinning down in order to obtain food.
Social interaction test:
Mouse is given the choice to interact with a novel object or a social partner
Mouse is given the choice to interact with a novel object or a social partner
January 29, 2025 at 4:41 PM
Social interaction test:
Mouse is given the choice to interact with a novel object or a social partner
Mouse is given the choice to interact with a novel object or a social partner
Elevated plus maze:
Mouse is placed in a cross-shaped platform with two open arms and two closed arms. Low anxiety mice will spend more time exploring the open arms.
Mouse is placed in a cross-shaped platform with two open arms and two closed arms. Low anxiety mice will spend more time exploring the open arms.
January 29, 2025 at 4:41 PM
Elevated plus maze:
Mouse is placed in a cross-shaped platform with two open arms and two closed arms. Low anxiety mice will spend more time exploring the open arms.
Mouse is placed in a cross-shaped platform with two open arms and two closed arms. Low anxiety mice will spend more time exploring the open arms.
Open field test:
Mice with high anxiety hide in the corners while those with lower anxiety will venture to the center to explore.
Mice with high anxiety hide in the corners while those with lower anxiety will venture to the center to explore.
January 29, 2025 at 4:41 PM
Open field test:
Mice with high anxiety hide in the corners while those with lower anxiety will venture to the center to explore.
Mice with high anxiety hide in the corners while those with lower anxiety will venture to the center to explore.