@bkwee.bsky.social
PhD student working on T cells and computer things @schumacher-lab.bsky.social at the NKI
I talked shortly 👍
#ATCR25 short talk 3: Bjorn Kwee on the possibility that TCR-epitope prediction is poor because the underlying data has more false positives than commonly believed.
May 27, 2025 at 2:46 PM
I talked shortly 👍
Reposted
#ATCR25 acceptance notifications just went out! We had 76 abstracts of very high quality, but could only accept 8 for short talks (so 10%). Huge thanks to our review committee for making though decisions. Really excited where the #TCR field is going based on the abstracts I saw!
May 6, 2025 at 8:01 AM
Reposted
Important work towards one of the holy grails in cancer immunotherapy: understanding/predicting/designing TCR specificities
It's not the models, it's the data!
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
A functionally validated TCR-pMHC database for TCR specificity model development
Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...
www.biorxiv.org
May 5, 2025 at 5:19 AM
Important work towards one of the holy grails in cancer immunotherapy: understanding/predicting/designing TCR specificities
Reposted
It's not the models, it's the data!
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
A functionally validated TCR-pMHC database for TCR specificity model development
Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...
www.biorxiv.org
May 2, 2025 at 3:57 PM
It's not the models, it's the data!
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...