in @cp-cellreports.bsky.social : Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design doi.org/10.1016/j.ce... "Here, we created a library of IOMA variants in which each SHM was individually reverted to the inferred germline counterpart [...]"

Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles: doi.org/10.1073/pnas... "We present approaches to elicit and identify cross-reactive mAbs that recognize conserved receptor-binding domain (RBD) epitopes using mosaic RBD nanoparticle immunizations in animals." @pnas.org

The answer lies in the differences between vaccines and antibiotics-and between the viruses and bacteria they fight. Vaccines stimulate the immune system to create a response without causing disease, while antibiotics kill bacteria during infections. 2/2 🧵

@caltech.edu asked Dr. Pamela Bjorkman "if overusing antibiotics can be harmful. Should we worry about overusing vaccines too?" The short answer is no.
Swipe to learn more from Caltech's Pamela Bjorkman.
#AskCaltech at caltech.edu/AskCaltech. 1/2

Excited to host @cwolberger.bsky.social today at @caltech.edu for our Biology and Biological Engineering Seminar!