bioRxiv Pharmacology and Toxicology
@biorxiv-pharma.bsky.social
Triclabendazole inhibits succinate dehydrogenase in vitro https://www.biorxiv.org/content/10.1101/2025.11.20.689426v1
November 23, 2025 at 5:01 PM
Triclabendazole inhibits succinate dehydrogenase in vitro https://www.biorxiv.org/content/10.1101/2025.11.20.689426v1
Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex https://www.biorxiv.org/content/10.1101/2025.11.21.689733v1
November 22, 2025 at 2:01 AM
Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex https://www.biorxiv.org/content/10.1101/2025.11.21.689733v1
Transcriptomic insights into developmental toxicity of per- and poly-fluoroalkyl substances (PFAS) in Caenorhabditis elegans: The potential key role of xenobiotic detoxification pathway https://www.biorxiv.org/content/10.1101/2025.11.21.689658v1
November 22, 2025 at 2:00 AM
Transcriptomic insights into developmental toxicity of per- and poly-fluoroalkyl substances (PFAS) in Caenorhabditis elegans: The potential key role of xenobiotic detoxification pathway https://www.biorxiv.org/content/10.1101/2025.11.21.689658v1
Nuclear α1A-Adrenergic Receptor Regulation of cAMP Production by an Inside-Out MAP Kinase Signaling Pathway in Cardiac Myocytes https://www.biorxiv.org/content/10.1101/2025.11.20.687712v1
November 21, 2025 at 10:01 PM
Nuclear α1A-Adrenergic Receptor Regulation of cAMP Production by an Inside-Out MAP Kinase Signaling Pathway in Cardiac Myocytes https://www.biorxiv.org/content/10.1101/2025.11.20.687712v1
Saxiphilin functions as a "toxin sponge" protein that counteracts the effects of saxitoxin poisoning https://www.biorxiv.org/content/10.1101/2025.11.20.689596v1
November 21, 2025 at 10:01 PM
Saxiphilin functions as a "toxin sponge" protein that counteracts the effects of saxitoxin poisoning https://www.biorxiv.org/content/10.1101/2025.11.20.689596v1
Anticancer potential of piericidin A1 and derivatives isolated from Streptomyces sp. associated with Palythoa variabilis from Brazilian Reefs https://www.biorxiv.org/content/10.1101/2025.11.19.689357v1
November 20, 2025 at 5:02 PM
Anticancer potential of piericidin A1 and derivatives isolated from Streptomyces sp. associated with Palythoa variabilis from Brazilian Reefs https://www.biorxiv.org/content/10.1101/2025.11.19.689357v1
The Effects of Garlic Extract on Renal Histopathology and Function in a Cadmium Chloride-Induced Hypertension Model https://www.biorxiv.org/content/10.1101/2025.11.19.689172v1
November 20, 2025 at 12:01 AM
The Effects of Garlic Extract on Renal Histopathology and Function in a Cadmium Chloride-Induced Hypertension Model https://www.biorxiv.org/content/10.1101/2025.11.19.689172v1
Absence of Sensory Cooling Activity and Cooling Agents from California's New ''Non-Menthol'' Cigarettes Marketed in 2025 https://www.biorxiv.org/content/10.1101/2025.11.17.688932v1
November 19, 2025 at 10:01 PM
Absence of Sensory Cooling Activity and Cooling Agents from California's New ''Non-Menthol'' Cigarettes Marketed in 2025 https://www.biorxiv.org/content/10.1101/2025.11.17.688932v1
Hepatocyte FGFR2 Mediates the Antifibrotic Effects of FGF10 in Advanced Liver Fibrosis. https://www.biorxiv.org/content/10.1101/2025.11.18.689001v1
November 18, 2025 at 9:01 PM
Hepatocyte FGFR2 Mediates the Antifibrotic Effects of FGF10 in Advanced Liver Fibrosis. https://www.biorxiv.org/content/10.1101/2025.11.18.689001v1
Pan-EphB tyrosine kinase inhibitor mitigates diabetic cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.11.17.688935v1
November 18, 2025 at 3:01 AM
Pan-EphB tyrosine kinase inhibitor mitigates diabetic cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.11.17.688935v1
UT-018, A Stem-Cell Chemoattractant Nutraceutical for intestinal Healing in DSS-Induced Colitis https://www.biorxiv.org/content/10.1101/2025.11.17.688808v1
November 18, 2025 at 2:00 AM
UT-018, A Stem-Cell Chemoattractant Nutraceutical for intestinal Healing in DSS-Induced Colitis https://www.biorxiv.org/content/10.1101/2025.11.17.688808v1
DETERMINATION OF CYTOTOXICITY AND FUNCTIONAL GROUPS IN THE RIGHT-WING OF MUSCA DOMESTICA https://www.biorxiv.org/content/10.1101/2025.11.11.687935v1
November 18, 2025 at 12:02 AM
DETERMINATION OF CYTOTOXICITY AND FUNCTIONAL GROUPS IN THE RIGHT-WING OF MUSCA DOMESTICA https://www.biorxiv.org/content/10.1101/2025.11.11.687935v1
Panax notoginseng saponins protect the blood brain barrier against oxidative stress by activating the Akap12/PI3K/AKT/AQP1 signaling axis https://www.biorxiv.org/content/10.1101/2025.11.14.688373v1
November 15, 2025 at 4:02 AM
Panax notoginseng saponins protect the blood brain barrier against oxidative stress by activating the Akap12/PI3K/AKT/AQP1 signaling axis https://www.biorxiv.org/content/10.1101/2025.11.14.688373v1
DNA adduct and mutational profiles reveal a threshold of cellular defenses against N-nitrosodimethylamine administered to mice in drinking water https://www.biorxiv.org/content/10.1101/2025.11.13.687536v1
November 15, 2025 at 3:00 AM
DNA adduct and mutational profiles reveal a threshold of cellular defenses against N-nitrosodimethylamine administered to mice in drinking water https://www.biorxiv.org/content/10.1101/2025.11.13.687536v1
TrkC has distinct spatiotemporal dynamics compared to TrkA and TrkB https://www.biorxiv.org/content/10.1101/2025.11.13.688325v1
November 14, 2025 at 9:01 PM
TrkC has distinct spatiotemporal dynamics compared to TrkA and TrkB https://www.biorxiv.org/content/10.1101/2025.11.13.688325v1
Off-target mapping enhances selectivity of machine learning-predicted CK2 inhibitors https://www.biorxiv.org/content/10.1101/2025.11.12.688093v1
November 14, 2025 at 1:01 AM
Off-target mapping enhances selectivity of machine learning-predicted CK2 inhibitors https://www.biorxiv.org/content/10.1101/2025.11.12.688093v1
High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics https://www.biorxiv.org/content/10.1101/2025.11.12.687995v1
November 13, 2025 at 6:01 PM
High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics https://www.biorxiv.org/content/10.1101/2025.11.12.687995v1
JPT2/HN1L functions as an NAADP-binding protein in a cell type-specific manner https://www.biorxiv.org/content/10.1101/2025.11.11.687795v1
November 12, 2025 at 10:01 PM
JPT2/HN1L functions as an NAADP-binding protein in a cell type-specific manner https://www.biorxiv.org/content/10.1101/2025.11.11.687795v1
Developmental exposure to a PFAS mixture impairs the anamnestic response to influenza A virus infection in mice https://www.biorxiv.org/content/10.1101/2025.11.10.687657v1
November 12, 2025 at 8:01 PM
Developmental exposure to a PFAS mixture impairs the anamnestic response to influenza A virus infection in mice https://www.biorxiv.org/content/10.1101/2025.11.10.687657v1
Adenosine-specific transcriptional programs in murine connective tissue type mast cells https://www.biorxiv.org/content/10.1101/2025.11.10.687562v1
November 12, 2025 at 12:01 AM
Adenosine-specific transcriptional programs in murine connective tissue type mast cells https://www.biorxiv.org/content/10.1101/2025.11.10.687562v1
A Study on the Pharmacokinetic/Pharmacodynamic Profiles of the Novel PPAR Pan Agonist Chiglitazar Sodium in Rats with Hypoalbuminemia https://www.biorxiv.org/content/10.1101/2025.11.09.687466v1
November 11, 2025 at 11:10 AM
A Study on the Pharmacokinetic/Pharmacodynamic Profiles of the Novel PPAR Pan Agonist Chiglitazar Sodium in Rats with Hypoalbuminemia https://www.biorxiv.org/content/10.1101/2025.11.09.687466v1
Effects of true to life polyethylene terephthalate and polycaprolactone nanoparticles on macrophages under a repeated exposure mode. https://www.biorxiv.org/content/10.1101/2025.11.08.687361v1
November 10, 2025 at 9:02 PM
Effects of true to life polyethylene terephthalate and polycaprolactone nanoparticles on macrophages under a repeated exposure mode. https://www.biorxiv.org/content/10.1101/2025.11.08.687361v1
Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival https://www.biorxiv.org/content/10.1101/2025.11.07.687263v1
November 10, 2025 at 6:02 PM
Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival https://www.biorxiv.org/content/10.1101/2025.11.07.687263v1
Serotonin 5-HT2C receptor as a cellular target of PI3K inhibitor LY294002 and its analog LY303511 https://www.biorxiv.org/content/10.1101/2025.11.06.687025v1
November 8, 2025 at 4:02 PM
Serotonin 5-HT2C receptor as a cellular target of PI3K inhibitor LY294002 and its analog LY303511 https://www.biorxiv.org/content/10.1101/2025.11.06.687025v1
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.11.05.686716v1
November 6, 2025 at 4:02 AM
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.11.05.686716v1