bioRxiv Biochemistry
@biorxiv-biochem.bsky.social
The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism https://www.biorxiv.org/content/10.1101/2025.11.13.686840v1
November 13, 2025 at 9:46 PM
The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism https://www.biorxiv.org/content/10.1101/2025.11.13.686840v1
HP1 dimerization but not LLPS drives the condensation and segregation of H3K9me-marked chromatin https://www.biorxiv.org/content/10.1101/2025.11.13.687974v1
November 13, 2025 at 9:45 PM
HP1 dimerization but not LLPS drives the condensation and segregation of H3K9me-marked chromatin https://www.biorxiv.org/content/10.1101/2025.11.13.687974v1
Structural promiscuity in the human circulatory IgA1 clonal repertoire https://www.biorxiv.org/content/10.1101/2025.11.13.688237v1
November 13, 2025 at 8:46 PM
Structural promiscuity in the human circulatory IgA1 clonal repertoire https://www.biorxiv.org/content/10.1101/2025.11.13.688237v1
The ABCs of Cyanobacterial Glycogen: In Vitro Modelling of Glycogen Synthesis and Functional Divergence of Glycogen Synthases in Synechocystis sp. PCC 6803 https://www.biorxiv.org/content/10.1101/2025.11.13.688228v1
November 13, 2025 at 8:46 PM
The ABCs of Cyanobacterial Glycogen: In Vitro Modelling of Glycogen Synthesis and Functional Divergence of Glycogen Synthases in Synechocystis sp. PCC 6803 https://www.biorxiv.org/content/10.1101/2025.11.13.688228v1
Breaking new ground into RAD51-BRC repeats interplay in Homologous Recombination https://www.biorxiv.org/content/10.1101/2025.11.13.688182v1
November 13, 2025 at 8:45 PM
Breaking new ground into RAD51-BRC repeats interplay in Homologous Recombination https://www.biorxiv.org/content/10.1101/2025.11.13.688182v1
Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification https://www.biorxiv.org/content/10.1101/2025.11.13.687868v1
November 13, 2025 at 8:45 PM
Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification https://www.biorxiv.org/content/10.1101/2025.11.13.687868v1
Photoclickable HaloTag Ligands for Spatiotemporal Multiplexed Protein Labeling on Living Cells https://www.biorxiv.org/content/10.1101/2025.11.13.686492v1
November 13, 2025 at 3:46 PM
Photoclickable HaloTag Ligands for Spatiotemporal Multiplexed Protein Labeling on Living Cells https://www.biorxiv.org/content/10.1101/2025.11.13.686492v1
Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system https://www.biorxiv.org/content/10.1101/2025.11.12.688083v1
November 13, 2025 at 3:45 AM
Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system https://www.biorxiv.org/content/10.1101/2025.11.12.688083v1
Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomas https://www.biorxiv.org/content/10.1101/2025.11.11.685192v1
November 13, 2025 at 2:46 AM
Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomas https://www.biorxiv.org/content/10.1101/2025.11.11.685192v1
Computational redesign of a thermostable T7 RNA polymerase https://www.biorxiv.org/content/10.1101/2025.11.12.688101v1
November 13, 2025 at 2:46 AM
Computational redesign of a thermostable T7 RNA polymerase https://www.biorxiv.org/content/10.1101/2025.11.12.688101v1
Exploration of American Elderberry Bioactive Compounds for Inhibition of the Influenza Virus Polymerase Acidic Endonuclease https://www.biorxiv.org/content/10.1101/2025.11.12.688002v1
November 13, 2025 at 2:45 AM
Exploration of American Elderberry Bioactive Compounds for Inhibition of the Influenza Virus Polymerase Acidic Endonuclease https://www.biorxiv.org/content/10.1101/2025.11.12.688002v1
Quantification of bioactive compounds in the juices of 21 American elderberry cultivars https://www.biorxiv.org/content/10.1101/2025.11.12.688025v1
November 13, 2025 at 2:45 AM
Quantification of bioactive compounds in the juices of 21 American elderberry cultivars https://www.biorxiv.org/content/10.1101/2025.11.12.688025v1
A Single-Aliquot, Enrichment-Free Workflow for High-Throughput Plasma Proteome and N-Glycoproteome Profiling https://www.biorxiv.org/content/10.1101/2025.11.11.687106v1
November 12, 2025 at 9:45 PM
A Single-Aliquot, Enrichment-Free Workflow for High-Throughput Plasma Proteome and N-Glycoproteome Profiling https://www.biorxiv.org/content/10.1101/2025.11.11.687106v1
Targeting ligand binding sites in Plasmodium falciparum NCR1 enables antimalarial drug discovery https://www.biorxiv.org/content/10.1101/2025.11.11.687791v1
November 12, 2025 at 2:45 AM
Targeting ligand binding sites in Plasmodium falciparum NCR1 enables antimalarial drug discovery https://www.biorxiv.org/content/10.1101/2025.11.11.687791v1
Ancestral neuronal receptors are bacterial accessory toxins https://www.biorxiv.org/content/10.1101/2025.11.11.687626v1
November 12, 2025 at 1:45 AM
Ancestral neuronal receptors are bacterial accessory toxins https://www.biorxiv.org/content/10.1101/2025.11.11.687626v1
Flux organizations and control modes in antagonistically combined negative feedback loops https://www.biorxiv.org/content/10.1101/2025.11.09.687434v1
November 11, 2025 at 4:45 AM
Flux organizations and control modes in antagonistically combined negative feedback loops https://www.biorxiv.org/content/10.1101/2025.11.09.687434v1
Untargeted Metabolomics of Plant Samples using HPLC-DAD and Gaussian Mixture Models https://www.biorxiv.org/content/10.1101/2025.11.10.687686v1
November 11, 2025 at 3:47 AM
Untargeted Metabolomics of Plant Samples using HPLC-DAD and Gaussian Mixture Models https://www.biorxiv.org/content/10.1101/2025.11.10.687686v1
Activation of oligonucleotide polyanions using collisions, electrons and photons in a timsOmni platform https://www.biorxiv.org/content/10.1101/2025.11.10.687689v1
November 11, 2025 at 3:46 AM
Activation of oligonucleotide polyanions using collisions, electrons and photons in a timsOmni platform https://www.biorxiv.org/content/10.1101/2025.11.10.687689v1
Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures https://www.biorxiv.org/content/10.1101/2025.11.09.687475v1
November 11, 2025 at 3:46 AM
Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures https://www.biorxiv.org/content/10.1101/2025.11.09.687475v1
Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention https://www.biorxiv.org/content/10.1101/2025.11.09.687522v1
November 11, 2025 at 2:46 AM
Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention https://www.biorxiv.org/content/10.1101/2025.11.09.687522v1
Structural basis of substrate recognition and membrane association by the bacterial lysyl-phosphatidylglycerol hydrolase AcvB https://www.biorxiv.org/content/10.1101/2025.11.10.687609v1
November 11, 2025 at 2:45 AM
Structural basis of substrate recognition and membrane association by the bacterial lysyl-phosphatidylglycerol hydrolase AcvB https://www.biorxiv.org/content/10.1101/2025.11.10.687609v1
Graph attention with structural features improves the generalizability of identifying functional sequences at a protein interface https://www.biorxiv.org/content/10.1101/2025.11.04.686550v1
November 11, 2025 at 2:45 AM
Graph attention with structural features improves the generalizability of identifying functional sequences at a protein interface https://www.biorxiv.org/content/10.1101/2025.11.04.686550v1
Structural insights into cobalamin loading and reactivation of human methionine synthase https://www.biorxiv.org/content/10.1101/2025.11.10.687659v1
November 11, 2025 at 1:45 AM
Structural insights into cobalamin loading and reactivation of human methionine synthase https://www.biorxiv.org/content/10.1101/2025.11.10.687659v1
A microvolume method for measuring catalase activity https://www.biorxiv.org/content/10.1101/2025.11.07.687299v1
November 10, 2025 at 4:46 AM
A microvolume method for measuring catalase activity https://www.biorxiv.org/content/10.1101/2025.11.07.687299v1
Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline https://www.biorxiv.org/content/10.1101/2025.11.08.686982v1
November 10, 2025 at 3:46 AM
Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline https://www.biorxiv.org/content/10.1101/2025.11.08.686982v1