Salvador Almagro-Moreno
@bioetry.bsky.social
Emergence and evolution of bacterial pathogens
Complexity in biological systems
Dept. of Host-Microbe Interactions
St. Jude Children's Research Hospital
NSF CAREER. BWF PATH
Complexity in biological systems
Dept. of Host-Microbe Interactions
St. Jude Children's Research Hospital
NSF CAREER. BWF PATH
The Host-Microbe Interactions Dept. representing @stjuderesearch.bsky.social at the amazing Microbial Pathogenesis and Host Response meeting at @cshlnews.bsky.social
September 12, 2025 at 3:42 PM
The Host-Microbe Interactions Dept. representing @stjuderesearch.bsky.social at the amazing Microbial Pathogenesis and Host Response meeting at @cshlnews.bsky.social
Had an amazing time at the legendary Molecular Genetics of Bacteria and Phages meeting in beautiful Madison!
August 9, 2025 at 5:05 PM
Had an amazing time at the legendary Molecular Genetics of Bacteria and Phages meeting in beautiful Madison!
Be cool like Snow
July 5, 2025 at 4:55 PM
Be cool like Snow
Happy hour for the Moreno Lab! So proud and excited to work with this amazing team of talented scientists. From left to right clockwise: Drs. Jane, Rachel, Qinqin, Oyinda, Salvador and Deepak.
July 3, 2025 at 10:15 PM
Happy hour for the Moreno Lab! So proud and excited to work with this amazing team of talented scientists. From left to right clockwise: Drs. Jane, Rachel, Qinqin, Oyinda, Salvador and Deepak.
Finally, we propose a model of emergence of the PCG highlighting how the emergence of this group has not been a linear process and contains a series of major bottlenecks that explains its rarity.
May 28, 2025 at 4:26 PM
Finally, we propose a model of emergence of the PCG highlighting how the emergence of this group has not been a linear process and contains a series of major bottlenecks that explains its rarity.
We wanted to elucidate the potential fitness costs associated with these alleles in the environment. To test this we stablished novel competition assays in a crustacean host, phytoplankton and mollusks.
May 28, 2025 at 4:26 PM
We wanted to elucidate the potential fitness costs associated with these alleles in the environment. To test this we stablished novel competition assays in a crustacean host, phytoplankton and mollusks.
Strikingly, a mutant encoding 6 non-PCG alleles was unable to colonize, suggesting these alleles provide a non-linear competitive advantage and act as a critical bottleneck that help elucidate the isolated emergence of PCG.
May 28, 2025 at 4:26 PM
Strikingly, a mutant encoding 6 non-PCG alleles was unable to colonize, suggesting these alleles provide a non-linear competitive advantage and act as a critical bottleneck that help elucidate the isolated emergence of PCG.
When we exchanged PCG-associated alleles for those of environmental strains, we found that some of them are essential for successful intestinal colonization (e.g. the TcpF allele of PCG) whereas others confer a range of competitive advantages.
May 28, 2025 at 4:26 PM
When we exchanged PCG-associated alleles for those of environmental strains, we found that some of them are essential for successful intestinal colonization (e.g. the TcpF allele of PCG) whereas others confer a range of competitive advantages.
Our analyses indicate that the emergence of PCG is largely dependent on the acquisition of unique modular gene clusters and allelic variations that confer a competitive advantage during intestinal colonization.
May 28, 2025 at 4:26 PM
Our analyses indicate that the emergence of PCG is largely dependent on the acquisition of unique modular gene clusters and allelic variations that confer a competitive advantage during intestinal colonization.
There are a number of elements associated with the emergence of the PCG. We looked at their distribution and composition in the V cholerae species.
May 28, 2025 at 4:26 PM
There are a number of elements associated with the emergence of the PCG. We looked at their distribution and composition in the V cholerae species.
Only one clade within the Vibrio cholerae species, the pandemic cholera group (PCG), can cause cholera in humans.
To understand the roots of PCG emergence, we performed one of the largest bioinformatic and genomic analyses of the V. cholerae species (>1800 genomes).
To understand the roots of PCG emergence, we performed one of the largest bioinformatic and genomic analyses of the V. cholerae species (>1800 genomes).
May 28, 2025 at 4:26 PM
Only one clade within the Vibrio cholerae species, the pandemic cholera group (PCG), can cause cholera in humans.
To understand the roots of PCG emergence, we performed one of the largest bioinformatic and genomic analyses of the V. cholerae species (>1800 genomes).
To understand the roots of PCG emergence, we performed one of the largest bioinformatic and genomic analyses of the V. cholerae species (>1800 genomes).
This should be compulsory: the meeting is either brief or we all end up jacked
May 18, 2025 at 2:25 PM
This should be compulsory: the meeting is either brief or we all end up jacked
I'd say this one
February 22, 2025 at 3:12 PM
I'd say this one
🚨 We also have a "Scientist" position in my lab at St. Jude. The position is financially stable and with a very competitive salary range.
📝 If you have Postdoctoral experience and want to develop a steady research career this one is for you!
➡️ Apply here:
talent.stjude.org/careers/jobs...
📝 If you have Postdoctoral experience and want to develop a steady research career this one is for you!
➡️ Apply here:
talent.stjude.org/careers/jobs...
January 20, 2025 at 3:52 PM
🚨 We also have a "Scientist" position in my lab at St. Jude. The position is financially stable and with a very competitive salary range.
📝 If you have Postdoctoral experience and want to develop a steady research career this one is for you!
➡️ Apply here:
talent.stjude.org/careers/jobs...
📝 If you have Postdoctoral experience and want to develop a steady research career this one is for you!
➡️ Apply here:
talent.stjude.org/careers/jobs...
And the move is now complete! Wohooo!
January 10, 2025 at 6:59 PM
And the move is now complete! Wohooo!
It’s “Science Christmas” for the Moreno Lab at St. Jude. Looking forward to setting things up!
January 8, 2025 at 7:56 PM
It’s “Science Christmas” for the Moreno Lab at St. Jude. Looking forward to setting things up!
Finally, we highlight how similar factors driving V. vulnificus disease dynamics affect other climate-sensitive pathogens. We hope our work will provide a blueprint to other researchers towards unearthing the complex relationship between infectious diseases and climate change.
December 17, 2024 at 10:22 AM
Finally, we highlight how similar factors driving V. vulnificus disease dynamics affect other climate-sensitive pathogens. We hope our work will provide a blueprint to other researchers towards unearthing the complex relationship between infectious diseases and climate change.
We discuss how climate change is affecting the spatiotemporal distribution of pathogenic Vibrio spp. I am still shocked by the numbers from Fig. 3C!
December 17, 2024 at 10:22 AM
We discuss how climate change is affecting the spatiotemporal distribution of pathogenic Vibrio spp. I am still shocked by the numbers from Fig. 3C!
Using hurricane impacts in Florida and V. vulnificus cases as an example, we show the role of these “unnatural”disasters in disease burden.
December 17, 2024 at 10:22 AM
Using hurricane impacts in Florida and V. vulnificus cases as an example, we show the role of these “unnatural”disasters in disease burden.
We discuss the influence of climate change on infectious disease burden in endemic and non-endemic areas.
December 17, 2024 at 10:22 AM
We discuss the influence of climate change on infectious disease burden in endemic and non-endemic areas.
Lamb shank rice, fried squid and lobster with hollandaise in my hometown Cádiz. Try to beat that 😎
December 15, 2024 at 10:07 PM
Lamb shank rice, fried squid and lobster with hollandaise in my hometown Cádiz. Try to beat that 😎
Microbial silver linings
November 22, 2024 at 11:19 PM
Microbial silver linings
Life of a scientist
November 15, 2024 at 11:47 AM
Life of a scientist