Yiyun Chen Group
@bio-photochem.bsky.social
Prof. Yiyun Chen's research group at Shanghai Institute of Organic Chemistry (SIOC), CAS, is working on biocompatible photochemistry, including organic photochemistry and photochemical biology.
Our lab's cover in @angewandtechemie.bsky.social! It showcases our work on photocatalytic proximity techniques using localized catalysts. This includes precise drug release with miniature photoenzymes and bioorthogonal protein labeling via ketyl radicals.
Inside Back Cover: Miniature Photoenzyme Enables Organelle‐Specific Cellular Control via Deboronative Hydroxylation
A compact, genetically encoded photoenzyme, miniSOG, enables spatiotemporally controlled bioorthogonal deboronative hydroxylation of diverse organoboronates in live cells by producing localized super....
onlinelibrary.wiley.com
November 30, 2025 at 4:02 AM
Our lab's cover in @angewandtechemie.bsky.social! It showcases our work on photocatalytic proximity techniques using localized catalysts. This includes precise drug release with miniature photoenzymes and bioorthogonal protein labeling via ketyl radicals.
Our latest work is out in @angewandtechemie.bsky.social: A miniature photoenzyme (12 kDa) uses visible light to achieve organelle-specific control in living cells via bioorthogonal deboronative hydroxylation. A powerful new platform for light-induced biological modulation.
Miniature Photoenzyme Enables Organelle‐Specific Cellular Control via Deboronative Hydroxylation
Genetically encoded miniature photoenzyme miniSOG (12 kDa) enables spatiotemporally controlled bioorthogonal deboronative hydroxylation of 27 diverse organoboronates in live cells via localized super...
onlinelibrary.wiley.com
November 30, 2025 at 3:58 AM
Our latest work is out in @angewandtechemie.bsky.social: A miniature photoenzyme (12 kDa) uses visible light to achieve organelle-specific control in living cells via bioorthogonal deboronative hydroxylation. A powerful new platform for light-induced biological modulation.
Our latest JACS @jacs.acspublications.org paper is out: Atomic-level precision protein labeling achieved in live cells using visible-light catalysis. This technology, based on stabilized ketyl radicals, provides a 'molecular ruler' to map protein dynamics and advance precision medicine.
Bioorthogonal Photocatalytic Protein Labeling and Cross-Linking Enabled by Stabilized Ketyl Radicals
Radical reactions offer transformative potential in biological contexts but remain constrained by poor selectivity and off-target reactivity. We address these limitations through visible-light photoca...
pubs.acs.org
November 30, 2025 at 3:47 AM
Our latest JACS @jacs.acspublications.org paper is out: Atomic-level precision protein labeling achieved in live cells using visible-light catalysis. This technology, based on stabilized ketyl radicals, provides a 'molecular ruler' to map protein dynamics and advance precision medicine.