BinderLab Basel
@binderlab.bsky.social
Out for the adaptive immune system in cancer, autoimmunity and infections @depbiomedicine.bsky.social. Lead by Mascha Binder.
www.binderlaboratory.com
www.binderlaboratory.com
Huge congrats to Christoph Schultheiß & Paul Schmidt-Barbo for this great work, and thanks to Ivona Aksentijevich & Daniel L. Kastner from NIH for their support! Read at JACI:
www.jacionline.org/article/S009...
www.jacionline.org/article/S009...
Deficiency of adenosine deaminase 2 skews adaptive immune repertoires towards specific sets of T and B cell receptors
Adenosine deaminase 2 deficiency (DADA2) is a genetic disorder caused by biallelic
hypomorphic or loss-of-function mutations in the ADA2 gene that encodes a protein
deaminase regulating extracellular ...
www.jacionline.org
February 9, 2025 at 11:12 AM
Huge congrats to Christoph Schultheiß & Paul Schmidt-Barbo for this great work, and thanks to Ivona Aksentijevich & Daniel L. Kastner from NIH for their support! Read at JACI:
www.jacionline.org/article/S009...
www.jacionline.org/article/S009...
We also developed a machine learning model that accurately distinguishes DADA2 patients from healthy individuals based solely on immune repertoire metrics, rather than sequence-level labels—shedding light on the unique immunogenetic signature of DADA2!
February 9, 2025 at 11:12 AM
We also developed a machine learning model that accurately distinguishes DADA2 patients from healthy individuals based solely on immune repertoire metrics, rather than sequence-level labels—shedding light on the unique immunogenetic signature of DADA2!
Congratulations to Claudia Fischer for this achievement and also many thanks to Matthias Peipp from UKSH, Heinz Läubli and Obinna Chijikoe @biomedizin.unibas.ch as well as Marie Follo @uniklinik-fr.bsky.social and Nicholas Chiorazzi from Feinstein Institutes, NY.
February 7, 2025 at 6:03 PM
Congratulations to Claudia Fischer for this achievement and also many thanks to Matthias Peipp from UKSH, Heinz Läubli and Obinna Chijikoe @biomedizin.unibas.ch as well as Marie Follo @uniklinik-fr.bsky.social and Nicholas Chiorazzi from Feinstein Institutes, NY.
We observed phenotypic differences in T cells based on production methods - even without antigen exposure. In addition, transposon-based production appears to promote an exhaustion-like phenotype via RIG-I sensing of transposase-encoding mRNA.
February 6, 2025 at 3:07 PM
We observed phenotypic differences in T cells based on production methods - even without antigen exposure. In addition, transposon-based production appears to promote an exhaustion-like phenotype via RIG-I sensing of transposase-encoding mRNA.