bethcd.bsky.social
@bethcd.bsky.social
Postdoc in infectious disease epidemiology and modelling at University of Cambridge. Interested in arboviruses, vaccines, and immunity. Previously at Imperial College London.
Our work helped inform WHO policy on dengue vaccines—supporting the strategic use of Qdenga where it can do the most good. Huge thanks to my PhD supervisors Ilaria Dorigatti & Neil Ferguson for the opportunity and their support on this project!
June 25, 2025 at 10:38 AM
Key findings:
1. Protection varies by serostatus & serotype
2. Cannot rule out an enhanced disease risk for seronegatives infected with serotypes 3 and 4, esp in children <6 years
3. Targeted Qdenga rollout (>6 yrs in high transmission settings) could still reduce hospitalisation burden by up to 20%
June 25, 2025 at 10:38 AM
We built a Bayesian model linking antibody titres to protection-by—serotype, age & serostatus—and embedded it in a transmission model to evaluate real-world impact across settings.
June 25, 2025 at 10:38 AM