Our research suggests a model for aging: Efficient mitochondrial energy production fuels nuclear maintenance of low methylation entropy.

Jonathan's genome shows variants in DNA repair & telomere regulation pathways. His methylome reveals age-related changes, with low entropy regions enriched for electron transport chain genes.

How do giant tortoises live so long? We sequenced the genome & methylome of 192-year-old Jonathan, revealing insights into his extreme longevity!
www.biorxiv.org/content/10.1...