Ben Pascoe
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Ben Pascoe
@benizao.bsky.social
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Senior Research Fellow at the University of Oxford using genomics to investigate the global spread and evolution of bacterial pathogens.

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We find more examples of these high resistance in global datasets - particularly in LMICs, and predominantly in lineages associated with chicken production (credit to @pubmlst.org)
Global, source, sequence type, and time distribution of the high-resistance cmeB gene from Campylobacter strains in the PubMLST database. Percentage of Campylobacter strains from various countries around the world with the RE-cmeB high-resistance gene (minimum 40 genomes).
December 30, 2024 at 5:16 PM
benizao.bsky.social
In our collection, most isolates with the high-resistance alleles were from specific lineages and more often found in commercial chicken isolates
Spread of high resistance RE-cmeRABC genotypes among Campylobacter isolates from children and chicken in Peru. Maximum likelihood phylogeny based on the 468 core genes shared among all 252 isolates, visualized separately for C. jejuni (A) and C. coli (B). Major lineages are labeled (ST-clonal complexes). Leaves colored by source; isolates from asymptomatic human carriage (gray), gastroenteritis cases (red), commercial poultry (orange), and home-reared poultry (yellow). Tree scale indicated as percentage of total alignment (412,566 bp), and all branches are supported by more than 1,000 bootstraps. Dotted lines indicate the threshold between clonal complexes for C. jejuni and C. coli. Distribution of susceptible and high-resistance cmeB alleles (RE-cmeRABC-associated alleles are shaded in yellow) among clonal complexes (C) and isolate source (D).
December 30, 2024 at 5:16 PM
benizao.bsky.social
Some of the discrepancy could be explained by the presence of "high-resistance" alleles of cmeB in the cmeABC efflux pump.
Dendrogram of Campylobacter isolates from Peru aligned with their antibiotic resistance profiles and presence of AMR determinants
December 30, 2024 at 5:16 PM