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bendavisgroup.bsky.social
Ben Davis Group
@bendavisgroup.bsky.social
36 followers 5 following 19 posts
Chemical Biology at the University of Oxford and the Rosalind Franklin Institute
"There is hope in honest error."
bendavis.group
http://orcid.org/0000-0002-5056-407X
https://scholar.google.co.uk/citations?hl=en&user=llfD9gsAAAAJ
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iwyp.org/wp-content/u...
November 5, 2025 at 8:49 PM
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doi.org/10.1021/acsc...
Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts
Design of modular, transferable protein assemblies has broad applicability and in structural biology could help with the ever-troublesome crystallization bottleneck, including finding robustly behaved...
doi.org
October 29, 2025 at 6:34 PM
bendavisgroup.bsky.social
www.biorxiv.org/content/10.1...
High-throughput discovery of a [4+3] dearomative cycloaddition enables dual photochemical-photophysical perturbative probing of protein function
Proteins exist in multiple conformations or states, often associated with different functional capacities. The ability to selectively identify and study these states is crucial for under-standing the ...
www.biorxiv.org
October 25, 2025 at 8:10 AM
bendavisgroup.bsky.social
www.nature.com/articles/s41...
Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM - Nature Chemical Biology
Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely...
www.nature.com
August 15, 2025 at 9:50 AM
bendavisgroup.bsky.social
www.biorxiv.org/content/10.1...
Biomolecular tracking by FIRESCAPE reveals distinct modes of clearance, damage induction and cellular uptake for extracellular histone H3
In attempting to observe the behaviour of a protein of interest in vivo, akin to other observer effects, current techniques require modifications or interventions that inherently alter the protein or ...
www.biorxiv.org
August 13, 2025 at 4:53 PM
bendavisgroup.bsky.social
www.nature.com/articles/s41...
Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications
The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...
www.nature.com
August 8, 2025 at 2:39 PM
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BGD has been awarded the ICS's Barry Cohen Award for Excellence in Medicinal Chemistry for 2025. www.chemistry.org.il/prizes-page/...
August 6, 2025 at 3:04 PM
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www.biorxiv.org/content/10.1...
Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygonal web architecture
A defining feature of Rift Valley fever virus (RVFV) is the incorporation of the NSs protein into large filamentous assemblies inside infected nuclei [1][1], as judged from fixed specimens. To gain in...
www.biorxiv.org
August 6, 2025 at 2:54 PM
bendavisgroup.bsky.social
www.nature.com/articles/s41...
Thio-NHS esters are non-innocent protein acylating reagents - Nature Communications
N-Hydroxysuccinimide (NHS)-ester derivatives are one of the most widely used acylating agents. In this work, the authors report that ring-opening reaction of the succinimide to afford N-succinamide de...
www.nature.com
July 1, 2025 at 3:37 PM
bendavisgroup.bsky.social
www.nature.com/articles/s41...
Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology
Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...
www.nature.com
June 26, 2025 at 12:16 PM
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www.nature.com/articles/s41...
Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials - Nature Biotechnology
A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.
www.nature.com
June 26, 2025 at 12:15 PM
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www.ox.ac.uk/news/2025-04...
New biostimulant treatment significantly boosts wheat yields, field
A novel biostimulant could deliver increased wheat yields of up to 12%, according to researchers from Oxford University, Rothamsted, and the Rosalind Franklin Institute in a long-term study published
www.ox.ac.uk
May 3, 2025 at 11:59 AM
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www.bbc.co.uk/programmes/m...
BBC Radio 4 - Farming Today, 30/4/25 Welsh community food strategy, British-grown pulses, biostimulant for wheat
New community food strategy for Wales.
www.bbc.co.uk
April 29, 2025 at 5:58 PM
bendavisgroup.bsky.social
Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine, Mol Cell Proteomics, 2025, 24(4), 100948, doi.org/10.1016/j.mc...
April 8, 2025 at 8:26 AM
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BGD has been awarded the ACS's Hudson Award for 2025. acscarb.org/awards/hudso...
March 31, 2025 at 3:26 PM
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Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers, bioRxiv 2025.01.26.634877; doi: doi.org/10.1101/2025...
Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers
The neurofilament light chain protein (NfL) is a suggested general marker for neuronal loss. Its release from brain parenchyma into cerebral spinal fluid, and presumed detection in blood has seen it e...
doi.org
March 1, 2025 at 3:16 PM
bendavisgroup.bsky.social
Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress, ACS Cent. Sci., 2025, 11, 107-115, doi.org/10.1021/acsc...
Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress
Protein N-glycosylation is a cotranslational modification that takes place in the endoplasmic reticulum (ER). Disruption of this process can result in accumulation of misfolded proteins, known as ER s...
doi.org
March 1, 2025 at 3:13 PM
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Structure of WzxE the Lipid III Flippase for Enterobacterial Common Antigen Polysaccharide, Open. Biol., 2025, 15, 240310, doi.org/10.1098/rsob...
Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide | Open Biology
The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the Enterobacterales order although its function is debated. ECA biogenesis depends on the Wzx/Wzy-dependent strategy...
doi.org
March 1, 2025 at 3:12 PM
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Start with some...Thoughts for the Future, Nature Chemical Biology, 2025, 21, 6-15; doi.org/10.1038/s415...
March 1, 2025 at 3:09 PM