Ben Clarke
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benclarkeuk.bsky.social
Ben Clarke
@benclarkeuk.bsky.social
340 followers 460 following 2 posts
Post doc in the Patani Lab at the National University of Singapore, interested in the role of glia in motor neuron disease using iPSC models
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#GliaPapers #GliaSpecial2025 REVIEW

Stanislaw Majewski, …, @benclarkeuk.bsky.social, Rickie Patani
www.crick.ac.uk/research/fin...

Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis
onlinelibrary.wiley.com/doi/10.1002/...
January 31, 2025 at 5:35 PM
benclarkeuk.bsky.social
Excited to share our new paper!Using iPSC-microglia with VCP mutations, we uncovered immune & lysosomal dysfunction. Secretome transfer revealed JAK-STAT activation in neurons & astrocytes. A big team effort over many years!

molecularneurodegeneration.biomedcentral.com/articles/10....
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB - Molecular Neurodegeneration
Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, ...
molecularneurodegeneration.biomedcentral.com
December 3, 2024 at 5:51 PM