Ben Auxier
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benauxier.bsky.social
Ben Auxier
@benauxier.bsky.social
Fungal geneticist interested in how fungi recognize themselves, and each other. Asst. Professor at WUR
Seems complicated, and I don't see any evidence for this?
November 11, 2025 at 10:45 AM
Finally, these Neurospora results build on similar results some of the authors demonstrated recently in two plant pathogenic fungi. Since these pathogens are less studied than Neurospora, we have do some experiments before a more formal response. But one is coming! www.science.org/doi/full/10....
www.science.org
November 10, 2025 at 8:50 PM
Finally, there are many, many studies that show conidia having multiple alleles, so they must be composed of different genetic nuclei (heterokaryotic). This has been shown both with mutants, as well as directly observed with fluorescence.
doi.org/10.1093/gene...
Permissiveness and competition within and between Neurospora crassa syncytia
Abstract. A multinucleate syncytium is a common growth form in filamentous fungi. Comprehensive functions of the syncytial state remain unknown, but it lik
doi.org
November 10, 2025 at 8:50 PM
Likewise, the classic experiments of Beadle and Tatum required extensive methods to isolate their mutations in a homokaryotic (pure nuclear) state. You cannot simply mutagenise Neurospora spores to get auxotrophs, something that is routinely in mononuclear haploid fungi like Aspergillus
November 10, 2025 at 8:50 PM
Bit longer version: The claim of a haploid, but mononuclear spore does not match with the extraordinarily common occurrence of transformation. Heterokaryons are commonly recovered, which would not be possible if they were truly haploid

www.biorxiv.org/content/10.1...
Breaking the ″one nucleus, one whole genome″ rule: Neurospora crassa separates its haploid chromosomes into different nuclei
Neurospora crassa has long served as a key fungal genetics model, facilitating discoveries like the ″one gene, one enzyme″ hypothesis. It produces many conidia, mostly with two or three nuclei and eac...
www.biorxiv.org
November 10, 2025 at 8:50 PM
I periodically rewatch this clip. How he uses jargon, but explains it each time. Particularly his focus on HOW the evidence leads to a conclusion. Seems to give a good model for science, that it is the interpretation that matters, not the "evidence". youtu.be/G8cbIWMv0rI?...
Carl Sagan - Cosmos - Eratosthenes
YouTube video by carlsagandotcom
youtu.be
November 9, 2025 at 7:56 PM
But... High school teacher is actually accurate??
November 7, 2025 at 8:04 PM
Have you considered posting this on something like PubPeer? A bit more permanent/searchable than Bleusky
November 1, 2025 at 8:22 PM
I guess there is *some* value for people who cannot easily ask colleagues, for example in a country with underdeveloped science. Sort of like how ChatGPY is helpful for grammar and stuff. Of course there is the problem that this not a real colleague, and so it makes a middle-of-the road paper.
October 16, 2025 at 7:20 PM