Ben Adler
@benadler.bsky.social
Postdoc @ Doudna Lab - UC-Berkeley | Bacteriophage engineering | CRISPR | Biotechnology | Microbiology | All Combinations Thereof | He/him. Opinions my own.
Reposted by Ben Adler
Panoptes guards the CBASS pathway (bacterial cGAS-STING). One facet of this work that I find particularly exciting is the genetic linkage between Panoptes and CBASS, which significantly co-occur in bacterial genomes. What other phage defense systems may be genetically (and functionally) linked?
October 8, 2025 at 11:14 AM
Panoptes guards the CBASS pathway (bacterial cGAS-STING). One facet of this work that I find particularly exciting is the genetic linkage between Panoptes and CBASS, which significantly co-occur in bacterial genomes. What other phage defense systems may be genetically (and functionally) linked?
Reposted by Ben Adler
Check out the complementary story from @doudna-lab.bsky.social led by @erinedoherty.bsky.social and @benadler.bsky.social Their work on OptE oligomerization is particularly crucial to completing our understanding of Panoptes. www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
October 8, 2025 at 11:14 AM
Check out the complementary story from @doudna-lab.bsky.social led by @erinedoherty.bsky.social and @benadler.bsky.social Their work on OptE oligomerization is particularly crucial to completing our understanding of Panoptes. www.nature.com/articles/s41...