Super grateful 💚 for support from my supervisors @drtesutherland.bsky.social @profjudiallen.bsky.social and Tony Day. Excited that we can continue to answer questions about immuno-matrix interactions in lung health thanks to support from @wellcometrust.bsky.social watch this space....

Parasite models have taught us so much about how the immune response is regulated - we think they can also teach us a lot about immune-mediated matrix formation and it's roles in effective (or not!) tissue repair

Mice that lack #IL-13 have a reduced type-2 response and we found they have less #HA at day 7 post infection... But IL-13 deficient mice have more tissue damage - highlighting an important IL-13-HA-tissue repair pathway that were investigating further 👀

The peak of HA in the lung coincides with the peak of the #type2immune response - which we know to be essential for effective #repair of the tissue damage caused by the parasite 🪱

Really interesting angle, and one we don't yet have the answer too. Certainly a possibility - CD44 binding to HA is highly dependent on how the HA is 'presented' to it. We've got lots more questions to answer and are looking forward to what we can uncover using these models! thank you 🙂