And last but not least, thanks to all the cryo-EM facilities (and their local contacts), where we optimized grids and collected cryo-EM data: @necen.bsky.social, @esrf.fr, BREM, CNIO, CIB and @lma-unizar.bsky.social and SAI @unizar.es

Many thanks to Carlos Vega-Gutiérrez, Irene Sánchez and Victoria Ribón from my lab at BIFI in @unizar.es, and Javier Picañol and David Soto from @ub.edu; thanks to all the funding agencies, @ageinves.bsky.social, FSE, and DGA,

While GluA4 shares the Y-shaped architecture of GluA2, during desensitization its LBD dimers rupture, resembling GluA1 and GluA3 complexes. This rupture is observed even under resting conditions. We also identified a new site for TARP modulation, located near the flip/flop region