Bryan Quach
@bcquach.bsky.social
Blending data science, DevOps, and bioinformatics expertise to tackle data and software engineering challenges in health tech and the life sciences
Reposted by Bryan Quach
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 1:31 AM
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Recent @biorxivpreprint.bsky.social preprint showing that HIV-1 viral rebound populations in women with HIV (N=10) were predominantly established around time of ART initiation
doi.org/10.1101/2025.01.29.635391
doi.org/10.1101/2025.01.29.635391
HIV-1 Rebound Virus Consists of a Small Number of Lineages That Entered the Reservoir Close to ART Initiation
HIV-1 persists as a latent reservoir during suppressive antiretroviral therapy (ART). Viral rebound occurs upon ART interruption, posing a challenge to cure efforts. Characterizing viral populations f...
doi.org
February 6, 2025 at 5:29 PM
Recent @biorxivpreprint.bsky.social preprint showing that HIV-1 viral rebound populations in women with HIV (N=10) were predominantly established around time of ART initiation
doi.org/10.1101/2025.01.29.635391
doi.org/10.1101/2025.01.29.635391
Reposted by Bryan Quach
Great and important review! Differences between Seurat and Scanpy have always been sort of a black box to me...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The impact of package selection and versioning on single-cell RNA-seq analysis
Standard single-cell RNA-sequencing analysis (scRNA-seq) workflows consist of converting raw read data into cell-gene count matrices through sequence alignment, followed by analyses including filterin...
www.biorxiv.org
December 16, 2024 at 9:06 PM
Great and important review! Differences between Seurat and Scanpy have always been sort of a black box to me...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bryan Quach
Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Multiscale footprints reveal the organization of cis-regulatory elements - Nature
We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.
www.nature.com
January 23, 2025 at 2:11 AM
Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...