Sebastian Swanson
@bassafras.bsky.social
Using computational methods to generate peptide therapeutics at Novo Nordisk | MIT PhD, Keating Lab | UMN Biochem | views are my own
That's actually super intriguing to me and a little hard to rationalize. Are most of the generated proteins at length ~1,000 still a single domain? I assume so if you're using TM-score, but that could be a confounding variable
November 19, 2023 at 10:46 PM
That's actually super intriguing to me and a little hard to rationalize. Are most of the generated proteins at length ~1,000 still a single domain? I assume so if you're using TM-score, but that could be a confounding variable
How many structures did you generate? It looks like once you get into the > 600 residue regime, Chroma->partialRFdiff->MPNN outperforms all other methods.
November 19, 2023 at 7:43 PM
How many structures did you generate? It looks like once you get into the > 600 residue regime, Chroma->partialRFdiff->MPNN outperforms all other methods.