@barthpd.bsky.social
Reposted
What does water do in the hidden depths of membrane protein function? A lot!
Now published in @naturechemistry.bsky.social, lnkd.in/ecb-ww5f, we rewire membrane protein allosteric networks via water to improve GPCR efficiency-a protein so vital for cells 1/3 of drugs target them.
Press release soon!
Now published in @naturechemistry.bsky.social, lnkd.in/ecb-ww5f, we rewire membrane protein allosteric networks via water to improve GPCR efficiency-a protein so vital for cells 1/3 of drugs target them.
Press release soon!
January 24, 2025 at 10:24 AM
What does water do in the hidden depths of membrane protein function? A lot!
Now published in @naturechemistry.bsky.social, lnkd.in/ecb-ww5f, we rewire membrane protein allosteric networks via water to improve GPCR efficiency-a protein so vital for cells 1/3 of drugs target them.
Press release soon!
Now published in @naturechemistry.bsky.social, lnkd.in/ecb-ww5f, we rewire membrane protein allosteric networks via water to improve GPCR efficiency-a protein so vital for cells 1/3 of drugs target them.
Press release soon!
Reposted
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks, from Patrick Bath and co-workers.
www.nature.com/articles/s41...
#chemsky
www.nature.com/articles/s41...
#chemsky
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks - Nature Chemistry
Solvent-mediated interaction networks control a wide range of protein functions, but their design has been neglected owing to a lack of accurate computational tools. Now it is shown that allosteric si...
www.nature.com
January 24, 2025 at 12:52 PM
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks, from Patrick Bath and co-workers.
www.nature.com/articles/s41...
#chemsky
www.nature.com/articles/s41...
#chemsky