Andrew Whitten
@awhitten.bsky.social
Berkeley chemistry PhD candidate in MChang Lab
Reposted by Andrew Whitten
Congratulations to former student Eli and the team on their new paper in Nature Chemical Biology! Here they show that the difference in radical rebound of FeII/aKG halogenases is uniquely controlled by the switching of the metal ligand bond axes! Take a look: www.nature.com/articles/s41...
Dynamic metal coordination controls chemoselectivity in a radical halogenase - Nature Chemical Biology
Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.
www.nature.com
November 21, 2025 at 3:18 PM
Congratulations to former student Eli and the team on their new paper in Nature Chemical Biology! Here they show that the difference in radical rebound of FeII/aKG halogenases is uniquely controlled by the switching of the metal ligand bond axes! Take a look: www.nature.com/articles/s41...
Reposted by Andrew Whitten
Congrats to lead author Doug and team on their new preprint, which describes a genome mining strategy to find non-canonical amino acid-based secondary metabolites outside of RiPP and NRPS pathways! Read more below: chemrxiv.org/engage/chemr...
tRNA-Deacylase Directed Discovery of Biosynthetic Pathways
Amino acids are one of nature’s most privileged building blocks for generating molecular diversity on length-scales ranging from small molecules to proteins. While amino acid products arising from cer...
chemrxiv.org
March 23, 2025 at 10:20 PM
Congrats to lead author Doug and team on their new preprint, which describes a genome mining strategy to find non-canonical amino acid-based secondary metabolites outside of RiPP and NRPS pathways! Read more below: chemrxiv.org/engage/chemr...
Reposted by Andrew Whitten
Biosynthesis of Strained Amino Acids Through a PLP-Dependent Enzyme via Cryptic Halogenation https://www.biorxiv.org/content/10.1101/2023.12.13.571568v1
Biosynthesis of Strained Amino Acids Through a PLP-Dependent Enzyme via Cryptic Halogenation https://www.biorxiv.org/content/10.1101/2023.12.13.571568v1
Amino acids (AAs) are modular and modifiable building blocks which nature uses to synthesize both ma
www.biorxiv.org
December 14, 2023 at 8:48 PM
Biosynthesis of Strained Amino Acids Through a PLP-Dependent Enzyme via Cryptic Halogenation https://www.biorxiv.org/content/10.1101/2023.12.13.571568v1