George Ghanim
@automnenine.bsky.social
Assistant Professor @ Princeton MolBio |
From transposons to telomeres and back | bicycles and biochemistry
https://ghanim.lab.princeton.edu
From transposons to telomeres and back | bicycles and biochemistry
https://ghanim.lab.princeton.edu
One of the more surprising parts was how the LINE-1 machinery (ORF2p) remodels the target DNA for retrotransposition - basically melting and breaking the DNA into two parts. We could even see this melting as heterogeneity during the #CryoEM data processing.
March 7, 2025 at 12:22 AM
One of the more surprising parts was how the LINE-1 machinery (ORF2p) remodels the target DNA for retrotransposition - basically melting and breaking the DNA into two parts. We could even see this melting as heterogeneity during the #CryoEM data processing.
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch
March 7, 2025 at 12:22 AM
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch