Are we ready for the next wegovy? At the #AsilomarChromatin conference and riveted by #TapasKumarKundu #JNCASR presentation on #MASH (formerly #NASH), #histone butyrylation, #adipogenesis, and LTK-14A a small molecule #p300-inhibitor. #obesity

Most definitely, #CoryPadilla #DovetailGenomics #CantataBio came to the right place ( #AsilomarChromatin Conference) to highlight the rapid and high-resolution #LinkPrep as an improved chromatin conformation capture approach.

At #AsilomarChromatin yesterday, #ShahirMorcos #UniversityofToronto #SickKids shared BioID analysis of BLBS #Histone H3.3 mutants showed altered interactions with PWWP-domain containing proteins that normally bind di/tri methylated H3K36. Could this be due to deregulation of methyltransferase?

Always thrilling to see #chromatin folks tackle brain disorders. At #AsilomarChromatin meeting, @mitchell-lab.bsky.social #UniversityofToronto proposes SRR2 (Sox2 Regulatory Region 2) enhancer deletion is possible mouse model for #schizophrenia because the ∆mice show loss of latent inhibition.

Cool talk by #ArpieBakhshian (#Padilla-Benavides lab, #WesleyanUniversity) @ the #AsilomarChromatin meeting on importance of copper in skeletal muscle differentiation (neat Cu-binding assay on western id's #CSRP2, Cysteine & Glycine Rich Protein 2) & showing sex difference in muscle regeneration.

Bryant-Li-Bhoj Syndrome (developmental delays/intellectual disability/craniofacial anomalies) is linked to Histone H3.3 mutations. #EricCampos #UniversityofToronto at today’s #AsilomarChromatin conference shared more H3.3 mutations & their consequence on modifications & protein interactions.

Gone BioID fishing with #ATRX? #AlejandroSaettone #UniversityofToronto #SickKids focused on chromatin-bound nuclear protein #CCDC71 (coiled-coil domain containing 71) and shared some ChIP-seq results to address where’s CCDC71?…and yes, we were a tad distracted by the fire. #AsilomarChromatin

#UCSC was well represented last night @ @asilomarchromatin.bsky.social conference with Alison Mills & Brandt Warecki (Sullivan lab). Watching movies of lagging chromosomes catch up so they’re not left behind is fascinating & makes me wonder how they “know” which cell to run to #AsilomarChromatin

Always been amazed how cells actually INTENTIONALLY cause double strand breaks. At @asilomarchroma last night, Cheyenne Sadeghi @FrockLab @Stanford showed evidence supporting that during #meiosis, #ATM kinase can suppress translocations after #SPO11 induces the meiotic double strand break.

Kicking off the 2024 @asilomarchromatin meeting with Maria Aristizabal Queen’s Univ drilling down on cancer-derived #histone mutations in budding yeast. Affect #genome integrity, transcription, and chromatin compaction! So cool that her first talk was THIS conference when she was an undergrad!

Let’s go! Less than two weeks to the 46th International Annual Asilomar #Chromatin, #Chromosomes, and #Epigenetics Conference Dec 12-15, 2024, in Pacific Grove, CA! asilomarchromatin.com #AsilomarChromatin