@asibc512.bsky.social
What a day! We published two papers describing the lives of proteins from Alpha shorturl.at/ZeAG7 to Omega shorturl.at/b79Eu
Seeing these processes through the lens of structural biology is so satisfying
Seeing these processes through the lens of structural biology is so satisfying
October 15, 2025 at 1:12 PM
What a day! We published two papers describing the lives of proteins from Alpha shorturl.at/ZeAG7 to Omega shorturl.at/b79Eu
Seeing these processes through the lens of structural biology is so satisfying
Seeing these processes through the lens of structural biology is so satisfying
Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
Nature Communications - K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin...
rdcu.be
October 15, 2025 at 10:16 AM
Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM
We discovered how an engineered ribosome arrest peptide (eRAP) acts as a built-in “pause button” to precisely control protein synthesis. eRAP merges two natural stalling systems to stop the ribosome at just the right time — shaping how nascent proteins begin to fold.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Validate User
academic.oup.com
October 15, 2025 at 2:28 AM
We discovered how an engineered ribosome arrest peptide (eRAP) acts as a built-in “pause button” to precisely control protein synthesis. eRAP merges two natural stalling systems to stop the ribosome at just the right time — shaping how nascent proteins begin to fold.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...