Ashley Tyrer
@ashleytyrer.bsky.social
Postdoc at @the-ecg.bsky.social, researching noradrenaline and decision-making with a sprinkle of Dynamic Causal Modelling and Active Inference 🧠
Blog Team Lead, OHBM Communications Committee 🤓 📰
https://www.researchgate.net/profile/Ashley-Tyrer
Blog Team Lead, OHBM Communications Committee 🤓 📰
https://www.researchgate.net/profile/Ashley-Tyrer
13/ I am hugely grateful to everyone on the Visceral Mind Project team for their help, and supervision from @micahgallen.com and @tobiasuhauser.bsky.social, without whom this project would not have been possible!
October 15, 2025 at 12:07 PM
13/ I am hugely grateful to everyone on the Visceral Mind Project team for their help, and supervision from @micahgallen.com and @tobiasuhauser.bsky.social, without whom this project would not have been possible!
9/ We also found negative correlations between markers of myeloarchitecture in the right postcentral gyrus & right superior parietal lobule, and value-free random exploration in short horizon trials - trials in which exploration is NOT beneficial!
October 15, 2025 at 12:03 PM
9/ We also found negative correlations between markers of myeloarchitecture in the right postcentral gyrus & right superior parietal lobule, and value-free random exploration in short horizon trials - trials in which exploration is NOT beneficial!
8/ We found greater indices of cortical myelination in right superior frontal brain regions - previously linked to impulsivity - to be strongly associated with increased value-free random exploration in long horizon trials, i.e., trials in which exploration is beneficial! 🧠
October 15, 2025 at 12:03 PM
8/ We found greater indices of cortical myelination in right superior frontal brain regions - previously linked to impulsivity - to be strongly associated with increased value-free random exploration in long horizon trials, i.e., trials in which exploration is beneficial! 🧠
7/ We then employed a TFCE-corrected, whole-brain multiple linear regression pipeline to examine how value-free random exploration relates to indices of brain microstructures (figure from Nikolova et al. 2025: www.jneurosci.org/content/45/3...).
October 15, 2025 at 12:02 PM
7/ We then employed a TFCE-corrected, whole-brain multiple linear regression pipeline to examine how value-free random exploration relates to indices of brain microstructures (figure from Nikolova et al. 2025: www.jneurosci.org/content/45/3...).
5/ In line with previous studies led by Magda Dubois and @tobiasuhauser.bsky.social, we found that participants increased their value-free random exploration in trials where exploration is beneficial (long horizon), compared with trials in which exploration is not beneficial (short horizon). 💡
October 15, 2025 at 12:00 PM
5/ In line with previous studies led by Magda Dubois and @tobiasuhauser.bsky.social, we found that participants increased their value-free random exploration in trials where exploration is beneficial (long horizon), compared with trials in which exploration is not beneficial (short horizon). 💡
3/ To investigate this behaviour, we combined the gamified multi-armed bandit task, Maggie’s Farm, with computational modelling to extract subject-specific parameters of exploration behaviours from 122 healthy human volunteers 🍎
October 15, 2025 at 11:58 AM
3/ To investigate this behaviour, we combined the gamified multi-armed bandit task, Maggie’s Farm, with computational modelling to extract subject-specific parameters of exploration behaviours from 122 healthy human volunteers 🍎
1/ To explore or to exploit? I’m excited to share my new preprint with @tobiasuhauser.bsky.social and @micahgallen.com, correlating variations in cortical microstructures with individual differences in exploration-exploitation behaviours, using a gamified task! 🧵 www.biorxiv.org/content/10.1...
October 15, 2025 at 11:57 AM
1/ To explore or to exploit? I’m excited to share my new preprint with @tobiasuhauser.bsky.social and @micahgallen.com, correlating variations in cortical microstructures with individual differences in exploration-exploitation behaviours, using a gamified task! 🧵 www.biorxiv.org/content/10.1...
Thanks so much to everyone who attended my DCM for Evoked Responses workshop on Saturday for #CPC2025 - it's always a pleasure to contribute 🙏🧠
#CPCZurich2025 #neuroskyence
#CPCZurich2025 #neuroskyence
September 9, 2025 at 12:36 PM
Thanks so much to everyone who attended my DCM for Evoked Responses workshop on Saturday for #CPC2025 - it's always a pleasure to contribute 🙏🧠
#CPCZurich2025 #neuroskyence
#CPCZurich2025 #neuroskyence
Looking forward to giving my Dynamic Casual Modelling for Evoked Responses workshop this afternoon, on another beautiful day in Zurich 😍🧠 #CPC2025 #neuroskyence
September 6, 2025 at 8:57 AM
Looking forward to giving my Dynamic Casual Modelling for Evoked Responses workshop this afternoon, on another beautiful day in Zurich 😍🧠 #CPC2025 #neuroskyence
That's a wrap for #CCN2025! Thanks again to everyone who came to my poster and discussed my research, it was great chatting to you all 😁🧠
#neuroskyence
#neuroskyence
August 18, 2025 at 11:33 AM
That's a wrap for #CCN2025! Thanks again to everyone who came to my poster and discussed my research, it was great chatting to you all 😁🧠
#neuroskyence
#neuroskyence
Gearing up for another day at #CCN2025! Catch me this afternoon at poster B168 in E-Hall where I'll be talking about my recent study on beta blockers and interoception 🧠+🫀🫁+💊
August 13, 2025 at 10:04 AM
Gearing up for another day at #CCN2025! Catch me this afternoon at poster B168 in E-Hall where I'll be talking about my recent study on beta blockers and interoception 🧠+🫀🫁+💊
Last Tuesday I was delighted to present my work on noradrenaline, decision-making, and interoception at the CFIN Summer School in Neuroimaging, @au.dk, including work from my most recent preprint! 🧠 💊
Read my preprint here: www.biorxiv.org/content/10.1...
Read my preprint here: www.biorxiv.org/content/10.1...
July 21, 2025 at 1:39 PM
Last Tuesday I was delighted to present my work on noradrenaline, decision-making, and interoception at the CFIN Summer School in Neuroimaging, @au.dk, including work from my most recent preprint! 🧠 💊
Read my preprint here: www.biorxiv.org/content/10.1...
Read my preprint here: www.biorxiv.org/content/10.1...
Last but certainly not least, we had Eryn presenting her elegant modelling of cuttlefish camouflage strategies 🌊 Based on what I've seen from these impressive early career researchers during the OCNC, the future is surely looking bright 🤩
July 15, 2025 at 11:22 AM
Last but certainly not least, we had Eryn presenting her elegant modelling of cuttlefish camouflage strategies 🌊 Based on what I've seen from these impressive early career researchers during the OCNC, the future is surely looking bright 🤩
India wowed us with her large-scale fMRI dataset examining cognitive reward sensitivity, with lots of potential for both neural and behavioural modelling! 🧠
July 15, 2025 at 11:18 AM
India wowed us with her large-scale fMRI dataset examining cognitive reward sensitivity, with lots of potential for both neural and behavioural modelling! 🧠
Daria presented her stunning work on non-linear dynamics of working memory using human intracranial EEG data 💭
July 15, 2025 at 11:13 AM
Daria presented her stunning work on non-linear dynamics of working memory using human intracranial EEG data 💭
Isabel worked incredibly hard on active inference modelling of her mouse behavioural data from a reversal learning task 🐁
July 15, 2025 at 11:11 AM
Isabel worked incredibly hard on active inference modelling of her mouse behavioural data from a reversal learning task 🐁
Lucy kicked off the student talks, presenting her modelling work on ocular following responses in marmosets 🐒
July 15, 2025 at 11:08 AM
Lucy kicked off the student talks, presenting her modelling work on ocular following responses in marmosets 🐒
Throughout the three weeks, I tutored five wonderful PhD students on their mini-projects completed as part of the course: Lucy Turner of University of Adelaide, Isabel Lau of Oxford University, Daria Kussovska of Columbia University, India Pinhorn of UCL, and Eryn Sale of UT Southwestern 🎓
July 15, 2025 at 11:03 AM
Throughout the three weeks, I tutored five wonderful PhD students on their mini-projects completed as part of the course: Lucy Turner of University of Adelaide, Isabel Lau of Oxford University, Daria Kussovska of Columbia University, India Pinhorn of UCL, and Eryn Sale of UT Southwestern 🎓
As well as giving my SPM software tutorial, I thoroughly enjoyed meeting all the students and guest lecturers, including @trackingactions.bsky.social @trackingskills.bsky.social and @tpvogels.bsky.social 🏖️
July 15, 2025 at 10:58 AM
As well as giving my SPM software tutorial, I thoroughly enjoyed meeting all the students and guest lecturers, including @trackingactions.bsky.social @trackingskills.bsky.social and @tpvogels.bsky.social 🏖️
Same place, seven years apart... For the past three weeks I've had the absolute pleasure of tutoring on the prestigious @oistedu.bsky.social Computational Neuroscience Course OCNC 2025 - seven years after I was selected to participate on the course as a student! 🧠
July 15, 2025 at 10:54 AM
Same place, seven years apart... For the past three weeks I've had the absolute pleasure of tutoring on the prestigious @oistedu.bsky.social Computational Neuroscience Course OCNC 2025 - seven years after I was selected to participate on the course as a student! 🧠
Thanks so much for having me at the #SPM course for #EEG and #MEG on Thursday to run my DCM for Evoked Responses workshop @imagingneuroucl.bsky.social, always a pleasure to spread the good #DCM news 🧠✨
May 24, 2025 at 12:40 PM
Thanks so much for having me at the #SPM course for #EEG and #MEG on Thursday to run my DCM for Evoked Responses workshop @imagingneuroucl.bsky.social, always a pleasure to spread the good #DCM news 🧠✨
11/ I am exceedingly grateful for all the help and supervision from @micahgallen.com, without whom this project would not have been possible! Also for the support of our lab @the-ecg.bsky.social, @lundbeckfonden.bsky.social, @erc.europa.eu and CFIN @au.dk 🙏
March 10, 2025 at 1:49 PM
11/ I am exceedingly grateful for all the help and supervision from @micahgallen.com, without whom this project would not have been possible! Also for the support of our lab @the-ecg.bsky.social, @lundbeckfonden.bsky.social, @erc.europa.eu and CFIN @au.dk 🙏
8/ To better understand these effects, we examined resting ECG data. As expected, both beta-blockers reduced heart rate, increased heart rate variability, and lowered sympathovagal balance compared with placebo, indicating a reduced sympathetic drive and enhanced vagal control.
March 10, 2025 at 1:46 PM
8/ To better understand these effects, we examined resting ECG data. As expected, both beta-blockers reduced heart rate, increased heart rate variability, and lowered sympathovagal balance compared with placebo, indicating a reduced sympathetic drive and enhanced vagal control.
6/ In the RRST, both drugs increased respiroceptive precision (less variability in breathing judgements) relative to placebo, with no effects on thresholds or metacognition. This suggests that only the consistency of judgements about breathing may be modulated by noradrenaline.
March 10, 2025 at 1:45 PM
6/ In the RRST, both drugs increased respiroceptive precision (less variability in breathing judgements) relative to placebo, with no effects on thresholds or metacognition. This suggests that only the consistency of judgements about breathing may be modulated by noradrenaline.
5/ Through hierarchical Bayesian modelling, we found that both drugs increased sensitivity to cardiac sensations (cardioceptive threshold) relative to placebo in the HRDT. Both drugs also increased metacognition for correct judgements, with bisoprolol exerting the strongest effect.
March 10, 2025 at 1:44 PM
5/ Through hierarchical Bayesian modelling, we found that both drugs increased sensitivity to cardiac sensations (cardioceptive threshold) relative to placebo in the HRDT. Both drugs also increased metacognition for correct judgements, with bisoprolol exerting the strongest effect.