Andrew Santiago-Frangos
@asantiagofrangos.bsky.social
Asst Prof @Penn. CRISPR Biology & Applications | DNA folding and Bacterial/Archaeal defense systems | Biochem & CryoEM | #NIHMOSAIC K99/R00.
https://web.sas.upenn.edu/sanfrango-lab/
https://web.sas.upenn.edu/sanfrango-lab/
New cryo-EM ❄️🔬 structures shine light on key steps in CRISPR-based adaptive immunity!
Viral DNA binding to the Cas1-2/3 integrase induces a conformational change needed to recruit the integrase to the CRISPR.
We capture how CRISPR repeat is unwound to allow complete integration. Congrats Will + co!
Viral DNA binding to the Cas1-2/3 integrase induces a conformational change needed to recruit the integrase to the CRISPR.
We capture how CRISPR repeat is unwound to allow complete integration. Congrats Will + co!
June 22, 2025 at 7:41 PM
New cryo-EM ❄️🔬 structures shine light on key steps in CRISPR-based adaptive immunity!
Viral DNA binding to the Cas1-2/3 integrase induces a conformational change needed to recruit the integrase to the CRISPR.
We capture how CRISPR repeat is unwound to allow complete integration. Congrats Will + co!
Viral DNA binding to the Cas1-2/3 integrase induces a conformational change needed to recruit the integrase to the CRISPR.
We capture how CRISPR repeat is unwound to allow complete integration. Congrats Will + co!
📢I'm hiring a Postdoc to join me at Dept. of Biology at UPenn! We'll use bioinformatics 🖥️, biochem 🧪, and cryo-EM ❄️🔬, to study how CRISPR systems work & applications. Work on cool science with a supportive mentor!
I'm still building up my Bluesky profile, so Reposts are appreciated!!!
I'm still building up my Bluesky profile, so Reposts are appreciated!!!
January 12, 2024 at 4:18 PM
📢I'm hiring a Postdoc to join me at Dept. of Biology at UPenn! We'll use bioinformatics 🖥️, biochem 🧪, and cryo-EM ❄️🔬, to study how CRISPR systems work & applications. Work on cool science with a supportive mentor!
I'm still building up my Bluesky profile, so Reposts are appreciated!!!
I'm still building up my Bluesky profile, so Reposts are appreciated!!!
The Santiago-Frangos lab is open and ready to do some exciting research on CRISPR biology and CRISPR applications! Ecstatic to be on UPenn's campus amongst such a supportive group of excellent scientists! 🤓
January 4, 2024 at 10:20 PM
The Santiago-Frangos lab is open and ready to do some exciting research on CRISPR biology and CRISPR applications! Ecstatic to be on UPenn's campus amongst such a supportive group of excellent scientists! 🤓