Isolating the genomic predictors and mechanisms of inbreeding and outbreeding depression allows us to better weigh their impacts and apply genetic rescue even when outbreeding depression is a risk. Many thanks to excellent coauthors, including @thatlionlady @frozen-zoo.bsky.social!

In an admixed breeding program, we found that the costs of inbreeding depression from genomic erosion outweigh outbreeding depression from chromosomal differences, suggesting that extinction risk is higher if populations remain isolated.