Artem Khan
@artemakhan.bsky.social
Graduate Fellow in the Birsoy Lab @RockefellerUniv | BIF PhD Fellow | NIDDK F99 Fellow | Previously: Princeton '21
Happy to see our recent work on SLC25A45 featured on the cover of @cp-cellmetabolism.bsky.social . Huge thanks to @yuyangliu.bsky.social for the design! @KivancBirsoy @rockefeller.edu
November 6, 2025 at 6:52 PM
Happy to see our recent work on SLC25A45 featured on the cover of @cp-cellmetabolism.bsky.social . Huge thanks to @yuyangliu.bsky.social for the design! @KivancBirsoy @rockefeller.edu
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and
SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as
a key mediator of mitochondrial impo...
www.cell.com
October 11, 2025 at 4:15 PM
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
Reposted by Artem Khan
Online Now: SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis Online now:
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Dias et al. discover that the orphan solute carrier protein, SLC25A45, enables mitochondrial import of methylated amino acids. SLC25A45-dependent mitochondrial uptake of trimethyllysine drives carnitine biosynthesis. Mutation near its C terminus impacts SLC25A45 proteostasis and associates with altered methylated amino acid levels in human plasma.
dlvr.it
October 10, 2025 at 3:19 PM
Online Now: SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis Online now:
Reposted by Artem Khan
Online now: Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial import of methylated amino acids and carnitine synthesis. Loss of Slc25a45 impairs fasting response by limiting carnitine availability for β-oxidation.
dlvr.it
October 10, 2025 at 3:43 PM
Online now: Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Excited to share our perspective on solute carrier transporters - gatekeepers of metabolism sciencedirect.com/science/arti... @KivancBirsoy
@YuyangLiu
@markgad.com
@TimCKenny
@cellpress.bsky.social
@rockefelleruniv.bsky.social
@YuyangLiu
@markgad.com
@TimCKenny
@cellpress.bsky.social
@rockefelleruniv.bsky.social
Solute carriers: The gatekeepers of metabolism
Solute carrier (SLC) proteins play critical roles in maintaining cellular and organismal homeostasis by transporting small molecules and ions. Despite…
sciencedirect.com
February 20, 2025 at 4:48 PM
Excited to share our perspective on solute carrier transporters - gatekeepers of metabolism sciencedirect.com/science/arti... @KivancBirsoy
@YuyangLiu
@markgad.com
@TimCKenny
@cellpress.bsky.social
@rockefelleruniv.bsky.social
@YuyangLiu
@markgad.com
@TimCKenny
@cellpress.bsky.social
@rockefelleruniv.bsky.social